{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:54:40Z","timestamp":1791172480579,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Many hypertensive patients require three or more antihypertensive agents to achieve target blood pressure. This randomized, double\u2010blind, multicenter phase 3 trial conducted in South Korea evaluated the efficacy and safety of a single\u2010pill triple combination therapy with valsartan (Val), amlodipine (Aml), and chlorthalidone (CTD) in patients whose blood pressure remained inadequately controlled on Val\/Aml dual therapy. Patients uncontrolled after 4 weeks of Val\/Aml 80\/5\u00a0mg were randomized 1:1 to either Val\/Aml\/CTD 80\/5\/12.5\u00a0mg or Val\/Aml 80\/5\u00a0mg using a double\u2010dummy design. After 2 weeks, doses were escalated to Val\/Aml\/CTD 160\/5\/25\u00a0mg or Val\/Aml 160\/5\u00a0mg, respectively, for a total treatment duration of 6 weeks. The primary endpoint was the change in mean sitting systolic blood pressure (MSSBP) from baseline to week 8. Of 193 randomized patients, 178 completed the study. The least squares mean \u00b1 SE change in MSSBP was \u221219.70 \u00b1 1.31\u00a0mmHg in the Val\/Aml\/CTD group versus \u22128.71 \u00b1 1.26\u00a0mmHg in the control group, yielding a statistically significant between\u2010group difference of \u221210.99 \u00b1 1.81\u00a0mmHg (95% CI, \u221214.56 to \u22127.41;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001). No serious adverse events occurred in the Val\/Aml\/CTD group, compared with an incidence of 1.98% in the control group (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.4985). Triple combination therapy with Val\/Aml\/CTD demonstrated superior blood pressure reduction and a favorable safety profile in patients with essential hypertension inadequately controlled on Val\/Aml dual therapy, supporting its use as an effective treatment option in this population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    : This trial was prospectively registered at ClinicalTrials.gov (identifier: NCT06416865).\n                  <\/jats:p>","DOI":"10.1111\/jch.70362","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:24:06Z","timestamp":1789107846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of a Single\u2010Pill Triple Combination of Valsartan, Amlodipine, and Chlorthalidone in Patients With Essential Hypertension Inadequately Controlled on Dual Therapy With Valsartan and Amlodipine: A Randomized, Double\u2010Blind, Multicenter, Phase 3 Trial"],"prefix":"10.1111","volume":"28","author":[{"given":"In\u2010Jeong","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Jun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Gyu","family":"Kong","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Soon Chun Hyang University Bucheon Hospital  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Ho","family":"Jo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Hallym University Sacred Heart Hospital  Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Joo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology College of Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Ung","family":"Choi","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Division of Cardiology Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine School of Medicine, Pusan National University  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Asan Medical Center Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chonnam National University Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Hyun","family":"Ihm","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine The Catholic University of Korea Bucheon St. Mary's Hospital  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook Bum","family":"Pyun","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine  Seoul Republic of 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