{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:54:39Z","timestamp":1791172479715,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Although carotid\u2010femoral pulse wave velocity (cf\u2010PWV) is the non\u2010invasive gold standard for assessing aortic stiffness, evidence linking cf\u2010PWV to basal ganglia enlarged perivascular spaces (BG\u2010EPVS) in the general population is limited. We aimed to evaluate this association and quantify the mediating role of blood pressure (BP) in community\u2010based adults. This cross\u2010sectional study included 485 participants from the Kailuan cohort. Cf\u2010PWV was measured by ultrasound, and BG\u2010EPVS were graded on 3.0\u2010Tesla MRI. Logistic regression, restricted cubic spline, and mediation analyses were applied to quantify the indirect effects of systolic BP (SBP), diastolic BP (DBP), and pulse pressure (PP). BG\u2010EPVS were identified in 59.4% of participants. After adjustment for cardiovascular risk factors other than BP, cf\u2010PWV \u2265\u00a010 m\/s was independently associated with BG\u2010EPVS (OR\u00a0=\u00a02.06, 95% CI: 1.27\u20133.36), with a linear dose\u2010response relationship (p for non\u2010linearity\u00a0=\u00a00.668). The association was stronger among participants aged \u2264\u00a070 years and among males. SBP and PP mediated 43.0% and 43.6% of the total cf\u2010PWV effect, respectively, whereas DBP did not function as a significant mediator. Higher cf\u2010PWV was independently and dose\u2010dependently associated with BG\u2010EPVS, with pulsatile BP components mediating approximately 43% of this association.<\/jats:p>","DOI":"10.1111\/jch.70363","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:31:53Z","timestamp":1789108313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood Pressure Mediates the Association Between Carotid\u2010Femoral Pulse Wave Velocity and Basal Ganglia Enlarged Perivascular Spaces: A Community\u2010Based Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Shang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound Beijing Haidian Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine  Shijiazhuang Hebei China"},{"name":"Hebei Provincial Hospital of Traditional Chinese Medicine  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kailuan General Hospital  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Kailuan General Hospital  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and EBM Unit Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases, State Key Lab of Digestive Health Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Quan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Beijing Friendship Hospital, Capital Medical University  Beijing 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