{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:54:39Z","timestamp":1791172479627,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    It remains unclear whether prehypertension combined with noncommunicable diseases (NCDs) is associated with higher risks of cardiovascular diseases (CVD) and all\u2010cause mortality. The study aimed to investigate the associations of\u00a0 prehypertension with CVD and all\u2010cause mortality in individuals with or without NCDs. The prospective cohort study included 56 114 participants from the Kailuan Study. Participants were divided into four groups: optimal blood pressure (BP) without NCDs, prehypertension without NCDs, optimal BP with NCDs and prehypertension with NCDs. CVD events and all\u2010cause mortality were followed up until December 31, 2018. Cox proportional hazards models and Kaplan\u2013Meier survival curves were used to assess the associations of prehypertension with the risk of CVD and all\u2010cause mortality among patients with or without NCDs. Sensitivity and stratified analysis were performed to verify the robustness of the results. During a median follow\u2010up of 9.04 years, 3367 CVD events and 5754 all\u2010cause mortality had occurred. Compared with optimal BP alone, the multivariable adjusted hazard ratios (HRs) and 95% confidence interval (CI) for CVD were 1.36(1.23\u20131.51) for prehypertension alone, 1.82(1.55\u20132.14) for optimal BP and NCDs and 2.33(2.10\u20132.58) for prehypertension and NCDs (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). For all\u2010cause mortality, the corresponding HRs (95%CI) were 1.13(1.04\u20131.21), 2.07(1.85\u20132.32) and 1.85(1.72\u20132.00) (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Results were consistent in sensitivity and stratified analysis. Notably, females with prehypertension and NCDs showed the highest all\u2010cause mortality risk. Prehypertension significantly increased CVD risk in patients with NCDs. However, a paradoxical all\u2010cause mortality association was seen, with higher risk among NCDs patients with optimal BP versus prehypertension.\n                  <\/jats:p>","DOI":"10.1111\/jch.70366","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:03:58Z","timestamp":1789725838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Diseases and All\u2010Cause Mortality Risk in Patients With Prehypertension and Noncommunicable Diseases: Results From the Kailuan Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Ruiying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Shengjing Hospital of China Medical University  Shenyang China"},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kailuan General Hospital North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kailuan General Hospital North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kailuan General Hospital North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kailuan General Hospital North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kailuan General Hospital North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renling","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Practice, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.08.015"},{"key":"e_1_2_11_3_1","first-page":"2560","volume-title":"JAMA","author":"Chobanian A. 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