{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:54:51Z","timestamp":1791172491080,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960315"],"award-info":[{"award-number":["81960315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360354"],"award-info":[{"award-number":["82360354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Brachial blood pressure may not fully reflect the multidimensional arterial load associated with left atrial\u2013left ventricular (LA\u2013LV) coupling. In this cross\u2010sectional study, we examined local carotid pulse wave velocity (PWV), cuff\u2010derived arterial pressure\u2013volume index (API), and arterial velocity\u2013pulse index (AVI), separately and as a composite afterload index (ACI), in 336 inpatients (71 controls, 183 with hypertension, and 82 with hypertension and type 2 diabetes). Covariate\u2010adjusted linear models related standardized exposures to the left atrial stiffness index (LASI) and LA\u2013LV coupling index (LACI). Greater ACI was associated with higher LACI (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    = 0.0142 per 1\u2010SD, 95% CI 0.0011\u20130.0273;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.033). The LASI estimate was directionally similar but less precise (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    = 0.0232, 95% CI \u22120.0024\u20130.0488;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.076), and all single\u2010domain CIs included zero. These findings support further evaluation of accessible multidomain vascular assessment as a complement to brachial blood pressure. External calibration and longitudinal validation are needed to establish the clinical value of ACI.\n                  <\/jats:p>","DOI":"10.1111\/jch.70368","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:50:46Z","timestamp":1790265046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidomain Arterial Afterload and Left Atrial\u2013Left Ventricular Coupling in Hypertensive Phenotypes"],"prefix":"10.1111","volume":"28","author":[{"given":"Yiran","family":"Luo","sequence":"first","affiliation":[{"name":"Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guizhou Medical University  Guiyang Guizhou China"},{"name":"Department of Ultrasound Center The Affiliated Hospital of Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Li","sequence":"additional","affiliation":[{"name":"Guizhou Medical University  Guiyang Guizhou China"},{"name":"Department of Ultrasound Center The Affiliated Hospital of Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Lu","sequence":"additional","affiliation":[{"name":"Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guizhou Medical University  Guiyang Guizhou China"},{"name":"Department of Ultrasound Center The Affiliated Hospital of Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.006023"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048123.22359.A0"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.0136"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003754"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834fa8b0"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312113507563"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2012.2170"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2021.01.003"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13574"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.43125"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010024\u201001831\u20103"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010020\u201000551\u20108"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy346"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2024.06.013"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.2020"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeae178"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.012"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1436"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.05.018"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.013"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeae033"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.02.001"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.12625"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.07.009"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.125.25985"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2025.04.011"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08327"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.320796"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.318317"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21618"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010023\u201002104\u2010y"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034646"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3651"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.704611"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.11.002"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201006291\u20104"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.03.024"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2025.27"}],"container-title":["The 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