{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T12:54:34Z","timestamp":1762520074906,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T00:00:00Z","timestamp":1361145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"NIH","award":["DK79155","41301"],"award-info":[{"award-number":["DK79155","41301"]}]},{"name":"Italian Ministry of Education"},{"name":"University and Research","award":["PRIN2009"],"award-info":[{"award-number":["PRIN2009"]}]},{"name":"Fondazione Del Monte di Bologna e Ravenna"},{"DOI":"10.13039\/501100005969","name":"University of Bologna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Taste signalling molecules are found in the gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) tract suggesting that they participate to chemosensing. We tested whether fasting and refeeding affect the expression of the taste signalling molecule, \u03b1\u2010transducin (G<jats:sub>\u03b1tran<\/jats:sub>), throughout the pig <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> tract and the peptide content of G<jats:sub>\u03b1tran<\/jats:sub> cells. The highest density of G<jats:sub>\u03b1tran<\/jats:sub>\u2010immunoreactive (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) cells was in the pylorus, followed by the cardiac mucosa, duodenum, rectum, descending colon, jejunum, caecum, ascending colon and ileum. Most G<jats:sub>\u03b1tran<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> cells contained chromogranin A. In the stomach, many G<jats:sub>\u03b1tran<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> cells contained ghrelin, whereas in the upper small intestine many were gastrin\/cholecystokinin\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> and a few somatostatin\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>. G<jats:sub>\u03b1tran<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> and G<jats:sub>\u03b1gust<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> colocalized in some cells. Fasting (24\u00a0h) resulted in a significant decrease in G<jats:sub>\u03b1tran<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> cells in the cardiac mucosa (29.3\u00a0\u00b1\u00a00.8 <jats:italic>versus<\/jats:italic> 64.8\u00a0\u00b1\u00a01.3, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05), pylorus (98.8\u00a0\u00b1\u00a01.7 <jats:italic>versus<\/jats:italic> 190.8\u00a0\u00b1\u00a01.9, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0\u00a0l), caecum (8\u00a0\u00b1\u00a00.01 <jats:italic>versus<\/jats:italic> 15.5\u00a0\u00b1\u00a00.5, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01), descending colon (17.8\u00a0\u00b1\u00a00.3 <jats:italic>versus<\/jats:italic> 23\u00a0\u00b1\u00a00.6, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) and rectum (15.3\u00a0\u00b1\u00a00.3 <jats:italic>versus<\/jats:italic> 27.5\u00a0\u00b1\u00a00.7, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Refeeding restored the control level of G<jats:sub>\u03b1tran<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> cells in the cardiac mucosa. In contrast, in the duodenum and jejunum, G<jats:sub>\u03b1tran<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> cells were significantly reduced after refeeding, whereas G<jats:sub>\u03b1tran<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> cells density in the ileum was not changed by fasting\/refeeding. These findings provide further support to the concept that taste receptors contribute to luminal chemosensing in the <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> tract and suggest they are involved in modulation of food intake and <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> function induced by feeding and fasting.<\/jats:p>","DOI":"10.1111\/jcmm.12026","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T00:38:37Z","timestamp":1361234317000},"page":"466-474","source":"Crossref","is-referenced-by-count":21,"title":["Expression and regulation of \u03b1\u2010transducin in the pig gastrointestinal tract"],"prefix":"10.1111","volume":"17","author":[{"given":"Maurizio","family":"Mazzoni","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Science University of Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"De Giorgio","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Italy"},{"name":"Centro Interdipartimentale di Ricerche sull'Alimentazione Umana (CIRAU) University of Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Latorre","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Science University of Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Vallorani","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Science University of Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bosi","sequence":"additional","affiliation":[{"name":"Department of Agri\u2010food Protection and Improvement University of Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Trevisi","sequence":"additional","affiliation":[{"name":"Department of Agri\u2010food Protection and Improvement University of Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Barbara","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Stanghellini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Corinaldesi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Forni","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Science University of Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Faussone\u2010Pellegrini","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Forensic Medicine University of Florence Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catia","family":"Sternini","sequence":"additional","affiliation":[{"name":"CURE\/DDRC, Division of Digestive Diseases, Departments Medicine and Neurobiology, David Geffen School of Medicine UCLA, Los Angeles, and Veterans Administration Greater Los Angeles Health System CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Clavenzani","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Science University of Bologna Italy"},{"name":"Centro Interdipartimentale di Ricerche sull'Alimentazione Umana (CIRAU) University of Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,18]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"9","article-title":"Luminal sensing in the gut: an overview","volume":"54","author":"Dockray GJ","year":"2003","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.277.5.G922"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e3282f43a73"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"G45761","DOI":"10.1152\/ajpgi.00411.2006","article-title":"Taste receptors in the gastrointestinal tract. 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