{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:55:31Z","timestamp":1771649731457,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T00:00:00Z","timestamp":1365379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontitis is a bacterially induced chronic inflammatory disease. Dental follicle progenitor cells (DFPCs) have been proposed as biological graft for periodontal regenerative therapies. The potential impact of bacterial toxins on DFPCs properties is still poorly understood. The aim of this study was to investigate whether DFPCs are able to sense and respond to lipopolysaccharide (LPS) from <jats:italic>Porphyromonas gingivalis<\/jats:italic>, a major periopathogenic bacterium. Specifically, we hypothesized that LPS could influence the migratory capacity and IL\u20106 secretion of DFPCs. DFPCs properties were compared to bone marrow mesenchymal stem cells (BMSCs), a well\u2010studied class of adult stem cells. The analysis by flow cytometry indicated that DFPCs, similar to BMSCs, expressed low levels of both toll\u2010like receptor (TLR) 2 and 4. The TLR4 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression was down\u2010regulated in response to LPS in both cell populations, while on protein level TLR4 was significantly up\u2010regulated on BMSCs. The TLR2 expression was not influenced by the LPS treatment in both DFPCs and BMSCs. The migratory efficacy of LPS\u2010treated DFPCs was evaluated by <jats:italic>in vitro<\/jats:italic> scratch wound assays and found to be significantly increased. Furthermore, we assayed the secretion of interleukin\u20106 (IL\u20106), a potent stimulator of cell migration. Interestingly, the levels of IL\u20106 secretion of DFPCs and BMSCs remained unchanged after the LPS treatment. Taken together, these results suggest that DFPCs are able to sense and respond to <jats:italic>P.\u00a0gingivalis<\/jats:italic> LPS. Our study provides new insights into understanding the physiological role of dental\u2010derived progenitor cells in sites of periodontal infection.<\/jats:p>","DOI":"10.1111\/jcmm.12058","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T06:34:38Z","timestamp":1365402878000},"page":"766-773","source":"Crossref","is-referenced-by-count":42,"title":["Dental follicle progenitor cells responses to <i><scp>P<\/scp>orphyromonas gingivalis <\/i><scp>LPS<\/scp>"],"prefix":"10.1111","volume":"17","author":[{"given":"Kyriaki","family":"Chatzivasileiou","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia A.","family":"Lux","sequence":"additional","affiliation":[{"name":"Reference and Translation Center for Cardiac Stem Cell Therapy (RTC) University of Rostock Rostock 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