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Increasing evidence from pre\u2010clinical studies supports preventive and therapeutic effects of mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s, also called mesenchymal stromal cells) in <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ARDS<\/jats:styled-content> (acute respiratory distress syndrome). Therapeutic effects of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s were noticed in various delivery approaches (systemic, local, or other locations), multiple origins (bone marrow or other tissues), or different schedules of administrations (before or after the challenges). <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s could reduce the over\u2010production of inflammatory mediators, leucocyte infiltration, tissue injury and pulmonary failure, and produce a number of benefit factors through interaction with other cells in the process of lung tissue repair. Thus, it is necessary to establish guidelines, standard operating procedures and evaluation criteria for translating <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\u2010based therapies into clinical application for patients with <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.12063","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T11:42:53Z","timestamp":1372851773000},"page":"927-935","source":"Crossref","is-referenced-by-count":35,"title":["Mesenchymal stem cells in acute lung injury: are they ready for translational medicine?"],"prefix":"10.1111","volume":"17","author":[{"given":"Feng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 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