{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:24:52Z","timestamp":1790619892800,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T00:00:00Z","timestamp":1379980800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>Telocytes (TC<\/jats:styled-content>), a cell population located in the connective tissue of many organs of humans and laboratory mammals, are characterized by a small cell body and extremely long and thin processes. Different TC<\/jats:styled-content> subpopulations share unique ultrastructural features, but express different markers. In the gastrointestinal (GI<\/jats:styled-content>) tract, cells with features of TC<\/jats:styled-content> were seen to be CD<\/jats:styled-content>34\u2010positive\/c\u2010kit\u2010negative and several roles have been proposed for them. Other interstitial cell types with regulatory roles described in the gut are the c\u2010kit\u2010positive\/CD<\/jats:styled-content>34\u2010negative\/platelet\u2010derived growth factor receptor \u03b1 (PDGFR<\/jats:styled-content>\u03b1)\u2010negative interstitial cells of C<\/jats:styled-content>ajal (ICC<\/jats:styled-content>) and the PDGFR<\/jats:styled-content>\u03b1\u2010positive\/c\u2010kit\u2010negative fibroblast\u2010like cells (FLC<\/jats:styled-content>). As TC<\/jats:styled-content> display the same features and locations of the PDGFR<\/jats:styled-content>\u03b1\u2010positive cells, we investigated whether TC<\/jats:styled-content> and PDGFR<\/jats:styled-content>\u03b1\u2010positive cells could be the same cell type. PDGFR<\/jats:styled-content>\u03b1\/CD<\/jats:styled-content>34, PDGFR<\/jats:styled-content>\u03b1\/c\u2010kit and CD<\/jats:styled-content>34\/c\u2010kit double immunolabelling was performed in full\u2010thickness specimens from human oesophagus, stomach and small and large intestines. All TC<\/jats:styled-content> in the mucosa, submucosa and muscle coat were PDGFR<\/jats:styled-content>\u03b1\/CD<\/jats:styled-content>34\u2010positive. TC<\/jats:styled-content> formed a three\u2010dimensional network in the submucosa and in the interstitium between muscle layers, and an almost continuous layer at the submucosal borders of muscularis mucosae and circular muscle layer. Moreover, TC<\/jats:styled-content> encircled muscle bundles, nerve structures, blood vessels, funds of gastric glands and intestinal crypts. Some TC<\/jats:styled-content> were located within the muscle bundles, displaying the same location of ICC<\/jats:styled-content> and running intermingled with them. ICC<\/jats:styled-content> were c\u2010kit\u2010positive and CD<\/jats:styled-content>34\/PDGFR<\/jats:styled-content>\u03b1\u2010negative. In conclusion, in the human GI<\/jats:styled-content> tract the TC<\/jats:styled-content> are PDGFR<\/jats:styled-content>\u03b1\u2010positive and, therefore, might correspond to the FLC<\/jats:styled-content>. We also hypothesize that in human gut, there are different TC<\/jats:styled-content> subpopulations probably playing region\u2010specific roles.<\/jats:p>","DOI":"10.1111\/jcmm.12134","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T10:31:51Z","timestamp":1389004311000},"page":"1099-1108","source":"Crossref","is-referenced-by-count":191,"title":["Telocytes express PDGFR<\/scp>\u03b1 in the human gastrointestinal tract"],"prefix":"10.1111","volume":"17","author":[{"given":"Maria\u2010Giuliana","family":"Vannucchi","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine Section of Anatomy and Histology University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Traini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Section of Anatomy and Histology University of Florence Florence 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