{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:11:05Z","timestamp":1769861465257,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To study the association between the polymorphisms Arg462Gln and Asp541Glu from the <jats:styled-content style=\"fixed-case\">RNASEL<\/jats:styled-content> gene (1q25), and the polymorphisms rs620861, rs1447295, rs6983267, rs7837328 from the chromosome 8q24 with the risk of presenting prostate cancer (<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>a) and its clinical characteristics in a <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ispanic (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hilean) population. The study was performed on 21 control patients and 83 patients diagnosed with <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>a. Polymorphisms were analysed from blood samples through real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> by using TaqMan probes, and the genetic analysis was performed with the <jats:styled-content style=\"fixed-case\">SNPS<\/jats:styled-content>tats program. Also, a comparison was performed between clinical characteristics of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>a and the presence of the different polymorphism genotypes by using the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>initab software. There was a significant association between the genotype G\/G from the polymorphism rs6983267 with an overall increased risk of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>a, in patients both with or without family history of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>a (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a04.47, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.05\u201318.94, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.034 and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a03.57, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.96\u201313.35, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.037, respectively). Regarding clinical parameters, patients carrying the genotype C\/C from the polymorphism Asp541Glu had significantly higher prostate\u2010specific antigen (<jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>) levels than patients carrying the other genotypes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.034). Moreover, patients with the genotype G\/G of rs6983267 had higher <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content> levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.024). The polymorphism rs6983267 from region 3 of the chromosome 8q24 appears to be a prominent risk factor for <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>a and a biomarker for cancer aggressiveness in the group of patients who presented higher levels of <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content> at the time of diagnosis.<\/jats:p>","DOI":"10.1111\/jcmm.12171","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T07:11:22Z","timestamp":1384413082000},"page":"125-133","source":"Crossref","is-referenced-by-count":23,"title":["Association of <scp>RNASEL<\/scp> and 8q24 variants with the presence and aggressiveness of hereditary and sporadic prostate cancer in a hispanic population"],"prefix":"10.1111","volume":"18","author":[{"given":"Ignacio F.","family":"San Francisco","sequence":"first","affiliation":[{"name":"Departamento de Urolog\u00eda Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo A.","family":"Rojas","sequence":"additional","affiliation":[{"name":"Departamento de Urolog\u00eda Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Torres\u2010Estay","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Fisiol\u00f3gicas Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Smalley","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n, Metabolismo y Diabetes Facultad Medicina Pontifica Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Cerda\u2010Infante","sequence":"additional","affiliation":[{"name":"Departamento de Hemato\u2010Oncolog\u00eda Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana P.","family":"Montecinos","sequence":"additional","affiliation":[{"name":"Departamento de Hemato\u2010Oncolog\u00eda Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Hurtado","sequence":"additional","affiliation":[{"name":"Laboratorio de Oncolog\u00eda y Gen\u00e9tica Molecular Cl\u00ednica Las Condes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro S.","family":"Godoy","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Fisiol\u00f3gicas Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"Department of Urology Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_7_3_1","volume-title":"Primer informe de registros poblacionales de cancer de Chile quinquenio 2003\u20132007","author":"Ministerio de Salud C"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00680-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000118690.05943.c0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5291.1371"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0702"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/342775"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/340450"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa075819"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.452"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.444"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2733"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp148"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031918"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35304-1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322008000300009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.07.068"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64999-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35617-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl268"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1157\/13078029"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-0985-x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601075"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00205"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21414"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.2011.778"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201959"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0315"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6541"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21235"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12171","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.12171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:28:15Z","timestamp":1696231695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,14]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/jcmm.12171"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12171","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,14]]}}}