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We investigated the histological and molecular features of MH<\/jats:styled-content> in left ventricle (LV<\/jats:styled-content>) regions of failing DCM<\/jats:styled-content> or ICM<\/jats:styled-content> hearts. We examined failing hearts from DCM<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a011; 41.9\u00a0\u00b1\u00a05.45\u00a0years; left ventricle\u2010ejection fraction (LV\u2010EF<\/jats:styled-content>), 18\u00a0\u00b1\u00a03.16%) and ICM<\/jats:styled-content> patients (n<\/jats:italic>\u00a0=\u00a012; 58.08\u00a0\u00b1\u00a01.7\u00a0years; LVEF<\/jats:styled-content>, 21.5\u00a0\u00b1\u00a06.08%) undergoing cardiac transplantation, and normal donor hearts (N, n<\/jats:italic>\u00a0=\u00a08). LV<\/jats:styled-content> inter\u2010ventricular septum (IVS<\/jats:styled-content>) and antero\u2010lateral free wall (FW<\/jats:styled-content>) were transmurally (i.e<\/jats:italic>. sub\u2010epicardial, mesocardial and sub\u2010endocardial layers) analysed. LV<\/jats:styled-content> glycogen content was shown to be increased in both DCM<\/jats:styled-content> and ICM<\/jats:styled-content> as compared with N hearts (P<\/jats:italic>\u00a0<\u00a00.001), with a U\u2010shaped transmural distribution (lower values in mesocardium). Capillary density was homogenously reduced in both DCM<\/jats:styled-content> and ICM<\/jats:styled-content> as compared with N (P<\/jats:italic>\u00a0<\u00a00.05 versus<\/jats:italic> N), with a lower decrease independent of the extent of fibrosis in sub\u2010endocardial and sub\u2010epicardial layers of DCM<\/jats:styled-content> as compared with ICM<\/jats:styled-content>. HIF<\/jats:styled-content>1\u2010\u03b1 and nestin, recognized ischaemic molecular hallmarks, were similarly expressed in DCM<\/jats:styled-content>\u2010LV<\/jats:styled-content> and ICM<\/jats:styled-content>\u2010LV<\/jats:styled-content> myocardium. The proteomic profile was overlapping by ~50% in DCM<\/jats:styled-content> and ICM<\/jats:styled-content> groups. Morphological and molecular features of MH<\/jats:styled-content> were detected in end\u2010stage ICM<\/jats:styled-content> as well as in end\u2010stage DCM LV<\/jats:styled-content>, despite epicardial coronary artery patency and lower fibrosis in DCM<\/jats:styled-content> hearts. Unravelling the presence of MH<\/jats:styled-content> in the absence of coronary stenosis may be helpful to design a novel approach in the clinical management of DCM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.12198","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T03:05:26Z","timestamp":1390273526000},"page":"396-414","source":"Crossref","is-referenced-by-count":43,"title":["Regional mapping of myocardial hibernation phenotype in idiopathic end\u2010stage dilated cardiomyopathy"],"prefix":"10.1111","volume":"18","author":[{"given":"Vincenzo","family":"Lionetti","sequence":"first","affiliation":[{"name":"Laboratory of Medical Science Institute of Life Sciences Scuola Superiore Sant'Anna Pisa Italy"},{"name":"Fondazione CNR\u2010Regione Toscana \u201cG. 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