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Our previous results indicate that keratinocytes from perilesional skin show the features of damaged cells. Sirtuins (silent mating type information regulation 2 homolog) 1, well\u2010known modulators of lifespan in many species, have a role in gene repression, metabolic control, apoptosis and cell survival, <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair, development, inflammation, neuroprotection and healthy ageing. In the literature there is no evidence for <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 signalling in vitiligo and its possible involvement in disease progression. Here, biopsies were taken from the perilesional skin of 16 patients suffering from non\u2010segmental vitiligo and <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 signalling was investigated in these cells. For the first time, a new SIRT1\/Akt, also known as Protein Kinase B (PKB)\/mitogen\u2010activated protein kinase (<jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>) signalling has been revealed in vitiligo. <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 regulates <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> pathway <jats:italic>via<\/jats:italic> Akt\u2010apoptosis signal\u2010regulating kinase\u20101 and down\u2010regulates pro\u2010apoptotic molecules, leading to decreased oxidative stress and apoptotic cell death in perilesional vitiligo keratinocytes. We therefore propose <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 activation as a novel way of protecting perilesional vitiligo keratinocytes from damage.<\/jats:p>","DOI":"10.1111\/jcmm.12206","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T16:54:52Z","timestamp":1389372892000},"page":"514-529","source":"Crossref","is-referenced-by-count":64,"title":["<scp>SIRT<\/scp>1 regulates <scp>MAPK<\/scp> pathways in vitiligo skin: insight into the molecular pathways of cell survival"],"prefix":"10.1111","volume":"18","author":[{"given":"Matteo","family":"Becatti","sequence":"first","affiliation":[{"name":"Department of Biochemical Sciences University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences University of Florence Florence 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