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When we used bioinformatics tools to search for the genes contributing to gynecological cancers, the expression of Olfactomedin 4 (<jats:styled-content style=\"fixed-case\">OLFM<\/jats:styled-content>4) was found by digital differential display to be associated with differentiation of endometrial adenocarcinoma. Aberrant expression of <jats:styled-content style=\"fixed-case\">OLFM<\/jats:styled-content>4 has been primarily reported in tumours of the digestive system. The mechanism of <jats:styled-content style=\"fixed-case\">OLFM<\/jats:styled-content>4 in tumuorigenesis is elusive. We investigated <jats:styled-content style=\"fixed-case\">OLFM<\/jats:styled-content>4 expression in endometrium, analysed the association of <jats:styled-content style=\"fixed-case\">OLFM<\/jats:styled-content>4 with <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> signalling in endometrial adenocarcinoma, and examined the roles of <jats:styled-content style=\"fixed-case\">OLFM<\/jats:styled-content>4 in endometrial adenocarcinoma. Expression of <jats:styled-content style=\"fixed-case\">OLFM<\/jats:styled-content>4 was increased during endometrial carcinogenesis, linked to the differentiation of endometrioid adenocarcinoma, and positively related to the expression of oestrogen receptor\u2010\u03b1 (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b1) and progesterone receptor. Moreover, <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b1\u2010mediated signalling regulated expression of <jats:styled-content style=\"fixed-case\">OLFM<\/jats:styled-content>4, and knockdown of <jats:styled-content style=\"fixed-case\">OLFM<\/jats:styled-content>4 enhanced proliferation, migration and invasion of endometrial carcinoma cells. Down\u2010regulation of <jats:styled-content style=\"fixed-case\">OLFM<\/jats:styled-content>4 was associated with decreased cumulative survival rate of patients with endometrioid adenocarcinoma. Our data suggested that impairment of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b1 signal\u2010mediated <jats:styled-content style=\"fixed-case\">OLFM<\/jats:styled-content>4 expression promoted the malignant progression of endometrioid adenocarcinoma, which may have significance for the therapy of this carcinoma.<\/jats:p>","DOI":"10.1111\/jcmm.12232","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T22:18:59Z","timestamp":1391552339000},"page":"863-874","source":"Crossref","is-referenced-by-count":21,"title":["Oestrogen receptor\u2010mediated expression of Olfactomedin 4 regulates the progression of endometrial adenocarcinoma"],"prefix":"10.1111","volume":"18","author":[{"given":"Chao","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital Sun Yat\u2010sen (Zhongshan) University Guangzhou 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