{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:36:22Z","timestamp":1760783782652},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Retinal neovascularization in retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>) is the most common cause of blindness for children. Despite evidence that hypoxia inducible factor (<jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>)\u20101\u03b1 \u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> axis is associated with the pathogenesis of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>, the inhibitors of <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101\u03b1 have not been established as a therapeutic target in the control of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> pathophysiology. We investigated the hypothesis that degradation of <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101\u03b1 as a master regulator of angiogenesis in hypoxic condition, using \u03b2\u2010lapachone, would confer protection against hypoxia\u2010induced retinopathy without affecting physiological vascular development in mice with oxygen\u2010induced retinopathy (<jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content>), an animal model of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>. The effects of \u03b2\u2010lapachone were examined after intraocular injection in mice with <jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content>. Intraocular administration of \u03b2\u2010lapachone resulted in significant reduction in hypoxia\u2010induced retinal neovascularization without retinal toxicity or perturbation of developmental retinal angiogenesis. Our results demonstrate that <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101\u03b1\u2013mediated <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> expression in <jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content> is associated with pathological neovascularization, not physiological angiogenesis. Thus, strategies blocking <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101\u03b1 in the developing eye in the pathological hypoxia could serve as a novel therapeutic target for <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.12235","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T11:43:34Z","timestamp":1392723814000},"page":"875-884","source":"Crossref","is-referenced-by-count":20,"title":["Beta\u2010lapachone inhibits pathological retinal neovascularization in oxygen\u2010induced retinopathy <i>via<\/i> regulation of <scp>HIF<\/scp>\u20101\u03b1"],"prefix":"10.1111","volume":"18","author":[{"given":"Sung Wook","family":"Park","sequence":"first","affiliation":[{"name":"Fight against Angiogenesis\u2010Related Blindness Laboratory Clinical Research Institute Seoul National University Hospital Seoul Korea"},{"name":"Department of Biomedical Sciences College of Medicine 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