{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:14:23Z","timestamp":1768677263003,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, we reported that human amniotic membrane\u2010derived mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">AMM<\/jats:styled-content>s) possess great angiogenic potential. In this study, we determined whether local injection of <jats:styled-content style=\"fixed-case\">AMM<\/jats:styled-content>s ameliorates peripheral neuropathy. <jats:styled-content style=\"fixed-case\">AMM<\/jats:styled-content>s were transplanted into injured sciatic nerves. <jats:styled-content style=\"fixed-case\">AMM<\/jats:styled-content> injection promoted significant recovery of motor nerve conduction velocity and voltage amplitude compared to human adipose\u2010derived mesenchymal stem cells. <jats:styled-content style=\"fixed-case\">AMM<\/jats:styled-content> implantation also augmented blood perfusion and increased intraneural vascularity. Whole\u2010mount fluorescent imaging analysis demonstrated that <jats:styled-content style=\"fixed-case\">AMM<\/jats:styled-content>s exhibited higher engraftment and endothelial incorporation abilities in the sciatic nerve. In addition, the higher expression of pro\u2010angiogenic factors was detected in <jats:styled-content style=\"fixed-case\">AMM<\/jats:styled-content>s injected into the peripheral nerve. Therefore, these data provide novel therapeutic and mechanistic insights into stem cell biology, and <jats:styled-content style=\"fixed-case\">AMM<\/jats:styled-content> transplantation may represent an alternative therapeutic option for treating peripheral neuropathy.<\/jats:p>","DOI":"10.1111\/jcmm.12249","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T06:17:03Z","timestamp":1396937823000},"page":"1028-1034","source":"Crossref","is-referenced-by-count":27,"title":["Amniotic mesenchymal stem cells display neurovascular tropism and aid in the recovery of injured peripheral nerves"],"prefix":"10.1111","volume":"18","author":[{"given":"YongNan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology The Fourth Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longzhe","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology College of Medicine Dong\u2010A University Busan Korea"},{"name":"Regional Clinical Trial Center Dong\u2010A University Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Sook","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ilsin Christian Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moo Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology College of Medicine Dong\u2010A University Busan Korea"},{"name":"Regional Clinical Trial Center Dong\u2010A University Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Whan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology College of Medicine Dong\u2010A University Busan Korea"},{"name":"Regional Clinical Trial Center Dong\u2010A University Hospital Busan Korea"},{"name":"Department of Anatomy and Cell Biology and Mitochondria Hub Regulation Center College of Medicine Dong\u2010A University Busan Korea"},{"name":"Innovative Cell &amp; 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