{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:47:23Z","timestamp":1790110043646,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T00:00:00Z","timestamp":1395360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preservation or restoration of normal alveolar epithelial barrier function is crucial for pulmonary oedema resolution. Keratinocyte growth factor\u20102 (<jats:styled-content style=\"fixed-case\">KGF<\/jats:styled-content>\u20102), a potent epithelial cell mitogen, may have a role in preventing ventilator\u2010induced lung injury (<jats:styled-content style=\"fixed-case\">VILI<\/jats:styled-content>), which occurs frequently in mechanically ventilated patients. The aim of the study was to test the role of <jats:styled-content style=\"fixed-case\">KGF<\/jats:styled-content>\u20102 in <jats:styled-content style=\"fixed-case\">VILI<\/jats:styled-content> in rats. Forty healthy adult male <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats were randomly allocated into four groups, where rats in Groups <jats:styled-content style=\"fixed-case\">HVZP<\/jats:styled-content> (high\u2010volume zero positive end\u2010expiratory pressure) and <jats:styled-content style=\"fixed-case\">HVZP<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">KGF<\/jats:styled-content>\u20102 were given intratracheally equal <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content> and 5\u00a0mg\/kg <jats:styled-content style=\"fixed-case\">KGF<\/jats:styled-content>\u20102 72\u00a0hrs before 4\u00a0hrs <jats:styled-content style=\"fixed-case\">HVZP<\/jats:styled-content> ventilation (20\u00a0ml\/kg), respectively, while <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">KGF<\/jats:styled-content>\u20102 were administered in the same manner in Groups Control and <jats:styled-content style=\"fixed-case\">KGF<\/jats:styled-content>\u20102, which underwent tracheotomy only with spontaneous breathing. Inflammatory cytokines (tumour necrosis factor\u2010\u03b1, macrophage inflammatory protein 2), neutrophil and total protein levels in bronchoalveolar lavage fluid and surfactant protein m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression in lung tissue were detected; the number of alveolar type II cells, lung water content and lung morphology were also evaluated. The results indicate that pre\u2010treatment with <jats:styled-content style=\"fixed-case\">KGF<\/jats:styled-content>\u20102 showed dramatic improvement in lung oedema and inflammation compared with <jats:styled-content style=\"fixed-case\">HVZP<\/jats:styled-content> alone, together with increased surfactant protein m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and alveolar type II cells. Our results suggest that <jats:styled-content style=\"fixed-case\">KGF<\/jats:styled-content>\u20102 might be considered a promising prevention for human <jats:styled-content style=\"fixed-case\">VILI<\/jats:styled-content> or other acute lung injury diseases.<\/jats:p>","DOI":"10.1111\/jcmm.12269","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T06:58:54Z","timestamp":1395385134000},"page":"1226-1235","source":"Crossref","is-referenced-by-count":24,"title":["Keratinocyte growth factor\u20102 intratracheal instillation significantly attenuates ventilator\u2010induced lung injury in rats"],"prefix":"10.1111","volume":"18","author":[{"given":"Jing","family":"Bi","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine 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