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This study investigated the paracrine effect of renal <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s on renal tubular epithelial cells (<jats:styled-content style=\"fixed-case\">TEC<\/jats:styled-content>s) <jats:italic>in vitro<\/jats:italic>, the regenerative function of renal <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s in renal tubules after ischaemia\u2013reperfusion injury (<jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content>) <jats:italic>in vivo<\/jats:italic> and the possible mechanisms involved. In a renal <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content> model, transplantation of renal <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s was found to decrease serum creatinine and blood urea nitrogen (<jats:styled-content style=\"fixed-case\">BUN<\/jats:styled-content>) levels, while renal fibroblasts exerted no such effect. The results of histological injury assessments and the expression levels of cleaved caspase\u20103 were consistent with a change in kidney function. Our data suggest that the protective effect of <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s against <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content> occurs <jats:italic>via<\/jats:italic> inflammation\u2010independent mechanisms <jats:italic>in vivo<\/jats:italic>. Furthermore, we found that renal <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s could not directly promote the proliferation and anti\u2010apoptosis properties of <jats:styled-content style=\"fixed-case\">TEC<\/jats:styled-content>s <jats:italic>in vitro<\/jats:italic>. <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s did not display any advantage in paracrine growth factor secretion <jats:italic>in vitro<\/jats:italic> compared with renal fibroblasts. These data indicate that renal <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s protect against renal <jats:styled-content style=\"fixed-case\">IRI <\/jats:styled-content><jats:italic>via<\/jats:italic> an inflammation\u2010independent pathway and that growth factors play a significant role in this mechanism. Renal <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s may protect <jats:styled-content style=\"fixed-case\">TEC<\/jats:styled-content>s in certain microenvironments while interacting with other cells.<\/jats:p>","DOI":"10.1111\/jcmm.12274","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T09:39:43Z","timestamp":1398332383000},"page":"1144-1156","source":"Crossref","is-referenced-by-count":52,"title":["Renal telocytes contribute to the repair of ischemically injured renal tubules"],"prefix":"10.1111","volume":"18","author":[{"given":"Liping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology Fudan University Zhongshan Hospital Shanghai China"},{"name":"Shanghai Key Lab of Organ Transplantation Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology Fudan University Zhongshan Hospital Shanghai China"},{"name":"Shanghai Key Lab of Organ Transplantation Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Fudan University Zhongshan Hospital Shanghai China"},{"name":"Shanghai Key Lab of Organ Transplantation Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rulin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Fudan University Zhongshan Hospital Shanghai China"},{"name":"Shanghai Key Lab of Organ Transplantation Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Fudan University Zhongshan Hospital Shanghai China"},{"name":"Shanghai Key Lab of Organ Transplantation Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guisheng","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Urology Fudan University Zhongshan Hospital Shanghai China"},{"name":"Shanghai Key Lab of Organ Transplantation Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology Fudan University Zhongshan Hospital Shanghai China"},{"name":"Shanghai Key Lab of Organ Transplantation Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiming","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Urology Fudan University Zhongshan Hospital Shanghai China"},{"name":"Shanghai Key Lab of Organ Transplantation Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology Fudan University Zhongshan Hospital Shanghai China"},{"name":"Shanghai Key Lab of Organ Transplantation Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,24]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"490","article-title":"Mechanisms of cellular injury in ischemic acute renal failure","volume":"18","author":"Sutton TA","year":"1998","journal-title":"Semin Nephrol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.10.1562"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90136-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/978-94-007-5690-8_38","volume-title":"Regeneration medicine. 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