{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:20:50Z","timestamp":1791271250529,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bone marrow\u2010derived mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s) could modulate inflammation in experimental lung injury. On the other hand, adrenergic receptor agonists could increase <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> synthesis of stem cells. Therefore, we investigated the therapeutic role of adrenaline\u2010stimulated <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s on lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>)\u2010induced lung injury. <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s were cultured with adrenergic receptor agonists or antagonists. Suspensions of lung cells or sliced lung tissue from animals with or without <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced injury were co\u2010cultured with <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s. <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010stimulated alveolar macrophages were co\u2010cultured with <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s (with adrenaline stimulation or not) in Transwell for 6\u00a0hrs. A preliminary animal experiment was conducted to validate the findings in <jats:italic>ex vivo<\/jats:italic> study. We found that adrenaline at 10\u00a0\u03bcM enhanced proliferation of <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s through both \u03b1\u2010 and \u03b2\u2010adrenergic receptors. Adrenaline promoted the migration of <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s towards <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010injured lung cells or lung tissue. Adrenaline\u2010stimulated <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s decreased the inflammation of <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010stimulated macrophages, probably through the expression and secretion of several paracrine factors. Adrenaline reduced the extent of injury in <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010injured rats. Our data indicate that adrenaline\u2010stimulated <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s might contribute to the prevention from acute lung injury through the activation of adrenergic receptors, promotion of proliferation and migration towards injured lung, and modulation of inflammation.<\/jats:p>","DOI":"10.1111\/jcmm.12283","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T06:27:14Z","timestamp":1396247234000},"page":"1612-1622","source":"Crossref","is-referenced-by-count":17,"title":["Adrenaline stimulates the proliferation and migration of mesenchymal stem cells towards the <scp>LPS<\/scp>\u2010induced lung injury"],"prefix":"10.1111","volume":"18","author":[{"given":"Xiaodan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Zhongshan Hospital Fudan University Shanghai 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