{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:12:44Z","timestamp":1790885564528,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T00:00:00Z","timestamp":1398816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hepatic fibrosis is concomitant with sinusoidal pathological angiogenesis, which has been highlighted as novel therapeutic targets for the treatment of chronic liver disease. Our prior studies have demonstrated that curcumin has potent antifibrotic activity, but the mechanisms remain to be elucidated. The current work demonstrated that curcumin ameliorated fibrotic injury and sinusoidal angiogenesis in rat liver with fibrosis caused by carbon tetrachloride. Curcumin reduced the expression of a number of angiogenic markers in fibrotic liver. Experiments\n                    <jats:italic>in vitro<\/jats:italic>\n                    showed that the viability and vascularization of rat liver sinusoidal endothelial cells and rat aortic ring angiogenesis were not impaired by curcumin. These results indicated that hepatic stellate cells (\n                    <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>\n                    s) that are characterized as liver\u2010specific pericytes could be potential target cells for curcumin. Further investigations showed that curcumin inhibited\n                    <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                    expression in\n                    <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>\n                    s associated with disrupting platelet\u2010derived growth factor\u2010\u03b2 receptor (\n                    <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\n                    \u2010\u03b2R)\/\n                    <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>\n                    and m\n                    <jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content>\n                    pathways.\n                    <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>\n                    motility and vascularization were also suppressed by curcumin associated with blocking\n                    <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\n                    \u2010\u03b2R\/focal adhesion kinase\/RhoA cascade. Gain\u2010 or loss\u2010of\u2010function analyses revealed that activation of peroxisome proliferator\u2010activated receptor\u2010\u03b3 (\n                    <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\n                    \u2010\u03b3) was required for curcumin to inhibit angiogenic properties of\n                    <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>\n                    s. We concluded that curcumin attenuated sinusoidal angiogenesis in liver fibrosis possibly by targeting\n                    <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>\n                    s\n                    <jats:italic>via<\/jats:italic>\n                    a\n                    <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\n                    \u2010\u03b3 activation\u2010dependent mechanism.\n                    <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\n                    \u2010\u03b3 could be a target molecule for reducing pathological angiogenesis during liver fibrosis.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12286","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T04:13:05Z","timestamp":1398831185000},"page":"1392-1406","source":"Crossref","is-referenced-by-count":130,"title":["Curcumin attenuates angiogenesis in liver fibrosis and inhibits 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Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Pharmacy Nanjing University of Chinese Medicine Nanjing China"},{"name":"Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing University of Chinese Medicine Nanjing China"},{"name":"National First\u2010Class Key Discipline for Traditional Chinese Medicine of Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,30]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1323","article-title":"Angiogenesis and liver fibrogenesis","volume":"24","author":"Valfre di Bonzo L","year":"2009","journal-title":"Histol 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