{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:55:07Z","timestamp":1768074907633,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T00:00:00Z","timestamp":1399334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The transition from liver fibrosis to hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) has been suggested to be a continuous and developmental pathological process. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) are recently discovered molecules that regulate the expression of genes involved in liver disease. Many reports demonstrate that miR\u2010483\u20105p and miR\u2010483\u20103p, which originate from miR\u2010483, are up\u2010regulated in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>, and their oncogenic targets have been identified. However, recent studies have suggested that miR\u2010483\u20105p\/3p is partially down\u2010regulated in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> samples and is down\u2010regulated in rat liver fibrosis. Therefore, the aberrant expression and function of miR\u2010483 in liver fibrosis remains elusive. In this study, we demonstrate that overexpression of miR\u2010483 <jats:italic>in vivo<\/jats:italic> inhibits mouse liver fibrosis induced by <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>. We demonstrate that miR\u2010483\u20105p\/3p acts together to target two pro\u2010fibrosis factors, platelet\u2010derived growth factor\u2010\u03b2 and tissue inhibitor of metalloproteinase 2, which suppress the activation of hepatic stellate cells (<jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">LX<\/jats:styled-content>\u20102. Our work identifies the pathway that regulates liver fibrosis by inhibiting the activation of <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/jcmm.12293","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T01:09:31Z","timestamp":1399424971000},"page":"966-974","source":"Crossref","is-referenced-by-count":56,"title":["Overexpression of miR\u2010483\u20105p\/3p cooperate to inhibit mouse liver fibrosis by suppressing the <scp>TGF<\/scp>\u2010\u03b2 stimulated <scp>HSC<\/scp>s in transgenic mice"],"prefix":"10.1111","volume":"18","author":[{"given":"Fuyuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"},{"name":"Translational Medicine Center of Northern China Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guodong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnosis Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"},{"name":"Department of Cell Biology Medical School Yangtze University Jingzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingzhu","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guixiang","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Harbin Medical University Harbin China"},{"name":"Translational Medicine Center of Northern China Harbin China"},{"name":"Basic Medical Institute of Heilongjiang Medical Science Academy Harbin China"},{"name":"Key Laboratory of Cardiovascular Medicine Research (Harbin Medical University) Ministry of Education Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Gerontology First Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040653"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00230.2013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00616-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2012.01578.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.87"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63539"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704894104"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23922"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.10.015"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.06.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.11.027"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1079"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200315109"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1820109"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1587"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-4456"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-1121-x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i22.2748"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101734108"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs113"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.14.1883"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.05.064"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.207456.112"},{"key":"e_1_2_7_25_1","first-page":"2719","article-title":"A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis","volume":"9","author":"Yao X","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139089"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1915510"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.177774.111"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.08.039"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.6.6.939"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2521"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12303"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)01301-G"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1653708"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn624"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3079"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.489302"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2441"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.06.010"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016081"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.01.001"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12293","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.12293","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:35:35Z","timestamp":1696163735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/jcmm.12293"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12293","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,6]]}}}