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Maternal infection can result in <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>. We investigated the ability of a <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>road <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>pectrum <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hemokine <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nhibitor (<jats:styled-content style=\"fixed-case\">BSCI<\/jats:styled-content>) to prevent infection\u2010induced <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> in mice. <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> was initiated in pregnant mice by intraperitoneal injection of lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>; 50\u00a0\u03bcg). Half the mice received <jats:styled-content style=\"fixed-case\">BSCI<\/jats:styled-content> (10\u00a0mg\/kg) 24\u00a0hrs prior to and immediately before <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> administration. The impact of <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> alone or <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">BSCI<\/jats:styled-content> was assessed on (<jats:italic>i<\/jats:italic>) injection\u2010to\u2010delivery interval, foetal survival rate, placental and neonates' weight; (<jats:italic>ii<\/jats:italic>) amniotic fluid and maternal plasma cytokine levels (by <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>uminex assay); foetal and maternal tissue cytokine gene expression levels (by Real\u2010Time <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>); (<jats:italic>iii<\/jats:italic>) immune cells infiltration into the uterine tissue (by stereological immunohistochemistry). Pre\u2010treatment with <jats:styled-content style=\"fixed-case\">BSCI<\/jats:styled-content> (<jats:italic>i<\/jats:italic>) decreased <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> (64% <jats:italic>versus<\/jats:italic> 100%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05); (<jats:italic>ii<\/jats:italic>) significantly attenuated cytokine\/chemokine expression in maternal tissues (plasma, liver, myometrium, decidua); (<jats:italic>iii<\/jats:italic>) significantly decreased neutrophil infiltration in the mouse myometrium. <jats:styled-content style=\"fixed-case\">BSCI<\/jats:styled-content>\u2010treated mice in which <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> was delayed till term had live foetuses with normal placental and foetal weight. <jats:styled-content style=\"fixed-case\">BSCI<\/jats:styled-content> represents a promising new class of therapeutics for <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>. In a mouse model of preterm labour, <jats:styled-content style=\"fixed-case\">BCSI<\/jats:styled-content> suppresses systemic inflammation in maternal tissues which resulted in the reduced incidence of <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010mediated <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>. These data provide support for efforts to target inflammatory responses as a means of preventing <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.12307","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T08:10:52Z","timestamp":1401869452000},"page":"1816-1829","source":"Crossref","is-referenced-by-count":67,"title":["Inhibition of infection\u2010mediated preterm birth by administration of broad spectrum chemokine inhibitor in mice"],"prefix":"10.1111","volume":"18","author":[{"given":"Oksana","family":"Shynlova","sequence":"first","affiliation":[{"name":"Lunenfeld Tanenbaum Research Institute Mount Sinai Hospital Toronto ON Canada"},{"name":"Department of Obstetrics &amp; Gynecology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Dorogin","sequence":"additional","affiliation":[{"name":"Lunenfeld Tanenbaum Research Institute 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