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We recently reported that the adult murine <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> contains a highly mobile population of Sca\u20101<jats:sup>+<\/jats:sup>Lin<jats:sup>\u2212<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:sup>\u2212<\/jats:sup> cells known as very small embryonic\/epiblast\u2010like stem cells (<jats:styled-content style=\"fixed-case\">VSEL<\/jats:styled-content>s) that express several markers of pluripotency such as Oct\u20104. In the <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> microenvironment, these cells are kept quiescent because of epigenetic modification of certain paternally imprinted genes. However, as reported, these cells can be mobilized in mice in an experimental model of stroke and express several genes involved in neurogenesis while circulating in peripheral blood (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>). In the current work, we employed a model of toxic brain damage, which is induced by administration of kainic acid, to see not only whether <jats:styled-content style=\"fixed-case\">VSEL<\/jats:styled-content>s can be mobilized into <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> in response to this neurotoxin, but, more importantly, whether they proliferate and expand in <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> tissue. We report here for the first time that brain damage leads to activation and expansion of the <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> pool of quiescent <jats:styled-content style=\"fixed-case\">VSEL<\/jats:styled-content>s, which precedes their subsequent egress into <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>. Harnessing these cells in neural tissue regeneration is currently one of the challenges in regenerative medicine.<\/jats:p>","DOI":"10.1111\/jcmm.12315","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T09:56:17Z","timestamp":1401875777000},"page":"1797-1806","source":"Crossref","is-referenced-by-count":21,"title":["Evidence that the population of quiescent bone marrow\u2010residing very small embryonic\/epiblast\u2010like stem cells (<scp>VSEL<\/scp>s) expands in response to neurotoxic treatment"],"prefix":"10.1111","volume":"18","author":[{"given":"Katarzyna","family":"Grymula","sequence":"first","affiliation":[{"name":"Department of Physiology Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Tarnowski","sequence":"additional","affiliation":[{"name":"Department of Physiology Pomeranian Medical University Szczecin 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