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However, there are urgent needs to have disease\u2010specific biomarkers to monitor the therapeutic efficacy and predict the patient prognosis. The present study overviewed proteomics\u2010based research on paediatric <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> to discuss important advances to combat cancer cells and search novel and real protein biomarkers of resistance or sensitivity to drugs which target the signalling networks. We highlighted the importance and significance of a proper phospho\u2010quantitative design and strategy for paediatric <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> between relapse and remission, when human body fluids from cerebrospinal, peripheral blood, or bone\u2010marrow were applied. The present article also assessed the schedule for the analysis of body fluids from patients at different states, importance of proteomics\u2010based tools to discover <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\u2010specific and sensitive biomarkers, to stimulate paediatric <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> research <jats:italic>via<\/jats:italic> proteomics to \u2018build\u2019 the reference map of the signalling networks from leukemic cells at relapse, and to monitor significant clinical therapies for <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\u2010relapse.<\/jats:p>","DOI":"10.1111\/jcmm.12319","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T02:42:41Z","timestamp":1402368161000},"page":"1239-1246","source":"Crossref","is-referenced-by-count":25,"title":["Proteomics\u2010based discovery of biomarkers for paediatric acute lymphoblastic leukaemia: challenges and 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