{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:48:32Z","timestamp":1790999312245,"version":"4.1.0"},"reference-count":86,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T00:00:00Z","timestamp":1408406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry for Science and Technology of the Republic of Slovenia","award":["J7-4050"],"award-info":[{"award-number":["J7-4050"]}]},{"name":"Ministry for Science and Technology of the Republic of Slovenia","award":["P1-0140"],"award-info":[{"award-number":["P1-0140"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Protein misfolding, and subsequent aggregation have been proven as the leading cause of most known dementias. Many of these, in addition to neurodegeneration, show profound changes in behaviour and thinking, thus, psychiatric symptoms. On the basis of the observation that progressive myoclonic epilepsies and neurodegenerative diseases share some common features of neurodegeneration, we proposed autophagy as a possible common impairment in these diseases. Here, we argue along similar lines for some neuropsychiatric conditions, among them depression and schizophrenia. We propose that existing and new therapies for these seemingly different diseases could be augmented with drugs used for neurodegenerative or neuropsychiatric diseases, respectively, among them some which modulate or augment autophagy.<\/jats:p>","DOI":"10.1111\/jcmm.12349","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T03:17:51Z","timestamp":1408504671000},"page":"1705-1711","source":"Crossref","is-referenced-by-count":43,"title":["Impaired autophagy: a link between neurodegenerative and neuropsychiatric diseases"],"prefix":"10.1111","volume":"18","author":[{"given":"Mira","family":"Polajnar","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular and Structural Biology Jo\u017eef Stefan Institute Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"\u017derovnik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular and Structural Biology Jo\u017eef Stefan Institute Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2119\/2007-00100.Irvine"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65184-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905529106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105681"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.12.027"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/418291a"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.07.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09859"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5389-07.2008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi900901e"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.19979"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/pri.18989"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt485"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307925110"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109761"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-09-0704"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06639"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04724"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04723"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.10.002"},{"key":"e_1_2_9_24_1","first-page":"305","article-title":"Aggresome formation","volume":"301","author":"Corboy MJ","year":"2005","journal-title":"Methods Mol Biol"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01852-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907967107"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32832986c4"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054511"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.20515"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2528"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00117-3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1362"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.10.031"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025416"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6189-11.2012"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.4.14541"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.110"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601758"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2012.00063"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8401-2"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2009.8"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206362109"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2009.07.006"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090202"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.27710"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.05.014"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws143"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.3.7662"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303510110"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70043-0"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b3888b"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.02.005"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.03.004"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.05.023"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.05.007"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.58891"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2008.07.005"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052023499"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.174"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.10.019"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2008.03.005"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3119-4"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm294"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708022105"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.05906.x"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200504035"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/417292a"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5467-07.2008"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100319200"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2013.02.001"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.12.050"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205011310040008"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2082"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.262"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.12.020"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.055"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.12.044"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.08.008"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2002.40201.x"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2002.1117"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.72"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4562-11.2012"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.163"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.07.014"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.315135"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00567"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.07.020"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12349","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.12349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:34:28Z","timestamp":1696278868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,19]]},"references-count":86,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/jcmm.12349"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12349","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,19]]}}}