{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:56:20Z","timestamp":1773420980538,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:00Z","timestamp":1412035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Korea Health Technology R&D project, Ministry of Health & Welfare","award":["HI13C1270"],"award-info":[{"award-number":["HI13C1270"]}]},{"name":"Korea Healthcare Technology R&D Project, Ministry of Health & Welfare","award":["A070001"],"award-info":[{"award-number":["A070001"]}]},{"name":"the National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["2013R1A1A2059998"],"award-info":[{"award-number":["2013R1A1A2059998"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, we reported the properties of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31\u2010expressing cells in healthy individuals. However, the characteristics of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31\u2010expressing cells derived from coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) patients remain unknown. This study aimed to investigate the relationship between circulating <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31<jats:sup>+<\/jats:sup> cells and <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> as well as their biological characteristics. Analysis with flow cytometry revealed that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31<jats:sup>+<\/jats:sup> cells (C\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31) from the peripheral blood (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>) of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients exhibited low levels of T\u2010cell marker and high levels of macrophage marker compared with the <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31<jats:sup>+<\/jats:sup> cells from healthy individuals (H\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31). In addition, the expression levels of multiple pro\u2010angiogenic and chemokine genes were significantly down\u2010regulated in C\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31. However, inflammatory gene <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<\/jats:italic>\u03b1 was highly up\u2010regulated in C\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31. Patients with unstable angina (<jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>) had significantly more <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31<jats:sup>+<\/jats:sup> cells in the <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> than healthy control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Moreover, there were significant correlations between the number of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31<jats:sup>+<\/jats:sup> cells and cardiovascular (<jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>) disease activity (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.318, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) and the number of diseased coronaries (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.312, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). For the diagnostic category of <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>, the area under curve was 0.803 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In conclusion, C\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31 have impaired angiogenic potential and the number of circulating <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31<jats:sup>+<\/jats:sup> cells were correlated with <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> risk. These findings may contribute to the understanding of the pathogenesis of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.12370","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T08:56:16Z","timestamp":1412067376000},"page":"2321-2330","source":"Crossref","is-referenced-by-count":18,"title":["Characteristics of circulating <scp>CD<\/scp>31<sup>+<\/sup> cells from patients with coronary artery disease"],"prefix":"10.1111","volume":"18","author":[{"given":"Moo Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Cardiology College of Medicine Dong\u2010A University Busan Korea"},{"name":"Regional Clinical Trial Center Dong\u2010A University Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longzhe","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology College of Medicine Dong\u2010A University Busan Korea"},{"name":"Regional Clinical Trial Center Dong\u2010A University Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Innovative Cell &amp; Gene Therapy Center International St. Mary's Hospital Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Whan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology College of Medicine Dong\u2010A University Busan Korea"},{"name":"Regional Clinical Trial Center Dong\u2010A University Hospital Busan Korea"},{"name":"Innovative Cell &amp; Gene Therapy Center International St. Mary's Hospital Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191259"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.3.221"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3422"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2000.00654.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/28.9.1301"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000163635.62927.34"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2873"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.449"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.4.1515"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.18-6-435"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.070"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.2.491"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000209948.50943.ea"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.07.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.11.097"},{"key":"e_1_2_7_17_1","unstructured":"LK Edwards 1993 M. 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