{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:19:23Z","timestamp":1791411563385,"version":"4.3.3"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 GM 087285-01"],"award-info":[{"award-number":["RO1 GM 087285-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"crossref","award":["123336"],"award-info":[{"award-number":["123336"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The endoplasmic reticulum (\n                    <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                    ) is an organelle important for protein synthesis and folding, lipid synthesis and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:roman>Ca<\/jats:roman>\n                    <\/jats:styled-content>\n                    <jats:sup>2+<\/jats:sup>\n                    homoeostasis. Consequently,\n                    <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                    stress or dysfunction affects numerous cellular processes and has been implicated as a contributing factor in several pathophysiological conditions. Tunicamycin induces\n                    <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                    stress in various cell types\n                    <jats:italic>in vitro<\/jats:italic>\n                    as well as\n                    <jats:italic>in vivo<\/jats:italic>\n                    . In mice, a hallmark of tunicamycin administration is the development of fatty livers within 24\u201348\u00a0hrs accompanied by hepatic\n                    <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                    stress. We hypothesized that tunicamycin would induce\n                    <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                    stress in adipose tissue that would lead to increased lipolysis and subsequently to fatty infiltration of the liver and hepatomegaly. Our results show that intraperitoneal administration of tunicamycin rapidly induced an\n                    <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                    stress response in adipose tissue that correlated with increased circulating free fatty acids (\n                    <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                    s) and glycerol along with decreased adipose tissue mass and lipid droplet size. Furthermore, we found that in addition to fatty infiltration of the liver as well as hepatomegaly, lipid accumulation was also present in the heart, skeletal muscle and kidney. To corroborate our findings to a clinical setting, we examined adipose tissue from burned patients where increases in lipolysis and the development of fatty livers have been well documented. We found that burned patients displayed significant\n                    <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                    stress within adipose tissue and that\n                    <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                    stress augments lipolysis in cultured human adipocytes. Our results indicate a possible role for\n                    <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                    stress induced lipolysis in adipose tissue as an underlying mechanism contributing to increases in circulating\n                    <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                    s and fatty infiltration into other organs.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12384","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T02:48:15Z","timestamp":1415414895000},"page":"82-91","source":"Crossref","is-referenced-by-count":53,"title":["Endoplasmic reticulum stress in adipose tissue augments lipolysis"],"prefix":"10.1111","volume":"19","author":[{"given":"Elena","family":"Bogdanovic","sequence":"first","affiliation":[{"name":"Division of Plastic Surgery Division of General Surgery Department of Surgery Department of Immunology University of Toronto Ross Tilley Burn Centre Sunnybrook Health Sciences Centre Sunnybrook Research Institute Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Kraus","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Division of General Surgery Department of Surgery Department of Immunology University of Toronto Ross Tilley Burn Centre Sunnybrook Health Sciences Centre Sunnybrook Research Institute Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Patsouris","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Division of General Surgery Department of Surgery Department of Immunology University of Toronto Ross Tilley Burn Centre Sunnybrook Health Sciences Centre Sunnybrook Research Institute Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Diao","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Division of General Surgery Department of Surgery Department of Immunology University of Toronto Ross Tilley Burn Centre Sunnybrook Health Sciences Centre Sunnybrook Research Institute Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Division of General Surgery Department of Surgery Department of Immunology University of Toronto Ross Tilley Burn Centre Sunnybrook Health Sciences Centre Sunnybrook Research Institute Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdikarim","family":"Abdullahi","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Division of General Surgery Department of Surgery Department of Immunology University of Toronto Ross Tilley Burn Centre Sunnybrook Health Sciences Centre Sunnybrook Research Institute Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc G","family":"Jeschke","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Division of General Surgery Department of Surgery Department of Immunology University of Toronto Ross Tilley Burn Centre Sunnybrook Health Sciences Centre Sunnybrook Research Institute Toronto ON 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