{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:24:25Z","timestamp":1782833065595,"version":"3.54.5"},"reference-count":248,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Italian Agency of Drug","award":["MRAR08P011-2012"],"award-info":[{"award-number":["MRAR08P011-2012"]}]},{"name":"Telethon","award":["GGP12040"],"award-info":[{"award-number":["GGP12040"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK73917"],"award-info":[{"award-number":["DK73917"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Statins competitively inhibit hepatic 3\u2010hydroxy\u20103\u2010methylglutaryl\u2010coenzyme A reductase, resulting in reduced plasma total and low\u2010density lipoprotein cholesterol levels. Recently, it has been shown that statins exert additional \u2018pleiotropic\u2019 effects by increasing expression levels of the membrane water channels aquaporin 2 (<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>2).<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>2 is localized mainly in the kidney and plays a critical role in determining cellular water content. This additional effect is independent of cholesterol homoeostasis, and depends on depletion of mevalonate\u2010derived intermediates of sterol synthetic pathways,<jats:italic>i.e<\/jats:italic>. farnesylpyrophosphate and geranylgeranylpyrophosphate. By up\u2010regulating the expression levels of<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>2, statins increase water reabsorption by the kidney, thus opening up a new avenue in treating patients with nephrogenic diabetes insipidus (<jats:styled-content style=\"fixed-case\">NDI<\/jats:styled-content>), a hereditary disease that yet lacks high\u2010powered and limited side effects therapy. Aspects related to water balance determined by<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>2 in the kidney, as well as standard and novel therapeutic strategies of<jats:styled-content style=\"fixed-case\">NDI<\/jats:styled-content>are discussed.<\/jats:p>","DOI":"10.1111\/jcmm.12422","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T12:50:46Z","timestamp":1421412646000},"page":"265-282","source":"Crossref","is-referenced-by-count":32,"title":["A novel therapeutic effect of statins on nephrogenic diabetes insipidus"],"prefix":"10.1111","volume":"19","author":[{"given":"Leonilde","family":"Bonfrate","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology Internal Medicine University Medical School Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Procino","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Biotechnologies and Biopharmaceutics University of Bari Aldo Moro Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Q.\u2010H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Saint Louis University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Svelto","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Biotechnologies and Biopharmaceutics University of Bari Aldo Moro Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology Internal Medicine University Medical School Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511163332001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.10.2528"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-004-0113-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811053391902"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00530-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00965-X"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.005"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.002"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67394-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.070675"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059344"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.2.1194"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/343425a0"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300119"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080531"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190413"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)91092-K"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq1101.098486"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8412"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C499"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1044"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.020818"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2007.01897.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568008054064850"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.03.010"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.35.22627"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02209-1"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(01)50001-7"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-013-0789-5"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.proghi.2004.03.001"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.110"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335762"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00024.2001"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V103647"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335116"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/361549a0"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01760.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1995.269.5.F663"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.269.3.C775"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e328364000d"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8140421"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117920"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11663"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115263"},{"key":"e_1_2_11_46_1","first-page":"F1","article-title":"Membrane recycling and epithelial cell function","volume":"256","author":"Brown D","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_11_47_1","first-page":"91","article-title":"Vasopressinergic and oxytocinergic pathways in the central nervous system","volume":"43","author":"Zimmerman EA","year":"1984","journal-title":"Fed Proc"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.45.32248"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00387.2002"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00001.2011"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600895103"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.4.1013"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0119577"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80034-8"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117525"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117079"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00476-P"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.3.578"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90370-4"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.35.22554"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8253"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.18.2295"},{"key":"e_1_2_11_63_1","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1242\/jcs.00355","article-title":"cAMP\u2010induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI","volume":"116","author":"Tamma G","year":"2003","journal-title":"J Cell Sci"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3610243"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.19.8984"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.278.2.F317"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00179.2003"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00257.2001"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012010079"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00109.2012"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00348.2012"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207339200"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.5.F874"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00431.2006"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.100"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2006.02.004"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000123804.18566.69"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200011000-00001"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.714"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.713"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198804073181403"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32386"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00491.2005"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9154"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39680"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00465.2007"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670100051"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2118-8"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00301-5"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00874020"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/790281"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh172"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.2.686"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200309017"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.043000"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1996.270.4.F657"},{"key":"e_1_2_11_97_1","first-page":"F213","article-title":"Downregulation of aquaporin\u20102 parallels changes in renal water excretion in unilateral ureteral obstruction","volume":"273","author":"Frokiaer J","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00090.2002"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12102019"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00387.2005"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00061.2005"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00394.2006"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.3122\/15572625-12-1-43"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.01.008"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.43"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117863"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077593"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119299"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007010092"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009060672"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800001105"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1967.04410010047006"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90369-8"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.29.5.613"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10336"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165x.2012.00488.x"},{"key":"e_1_2_11_117_1","first-page":"53","article-title":"Urinary concentrating ability and antidiuretic hormone responsiveness in the potassium\u2010depleted dog","volume":"100","author":"Rutecki GW","year":"1982","journal-title":"J Lab Clin Med"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108813"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118628"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.4.F655"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.66036.x"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033145"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2008.04.028"},{"key":"e_1_2_11_124_1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2460\/javma.1987.191.09.1130","article-title":"Pyometra in cats: 183 cases (1979\u20101984)","volume":"191","author":"Kenney KJ","year":"1987","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00378.x"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708350200"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90607.2008"},{"key":"e_1_2_11_128_1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2460\/javma.1988.193.04.457","article-title":"Renal dysfunction in dogs with pyometra","volume":"193","author":"Stone EA","year":"1988","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9594"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502236102"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00337.2004"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00439.2010"},{"key":"e_1_2_11_133_1","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1074\/jbc.R600038200","article-title":"Prostaglandin E receptors","volume":"282","author":"Sugimoto Y","year":"2006","journal-title":"J Biol Chem"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.579"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1104691108"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121267"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197603042941001"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07667-5"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0366"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-2057-8"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1195-0"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00426.x"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104657"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81106-0"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0660709"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)81010-1"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00248.2011"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00359.2009"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-011-1007-5"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.10"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.153"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000138236.82706.EE"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0608382"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000196564.18314.23"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2006.08.006"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.278.3.F388"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1974.tb09708.x"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330891"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2011.02.017"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.06.007"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.7.5136"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.1.115"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh1701.096614"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200113152"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109938"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00437.2005"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2000.011205.x"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/263515a0"},{"key":"e_1_2_11_169_1","first-page":"R932","article-title":"Exogenous vasopressin reverses hyperactivity in the hypothalamus of Brattleboro rats","volume":"247","author":"Krukoff TL","year":"1984","journal-title":"Am J Physiol"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.03.013"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.058008"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960261507"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm807"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.555482"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077704"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00779-3"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248407306676"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.472"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(99)01710-9"},{"issue":"6","key":"e_1_2_11_180_1","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1242\/jcs.107.6.1661","article-title":"Association of Rap1a and Rap1b proteins with late endocytic\/phagocytic compartments and Rap2a with the Golgi complex","volume":"107","author":"Pizon V","year":"1994","journal-title":"J Cell Sci"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000136778.32499.05"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.557652"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1603"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1602"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.6.5.573"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1281"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.03.008"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.02.030"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100908"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010012"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-2-200301210-00010"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/456076"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg143"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.1009"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.11.2152"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl538"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl244"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-005-5686-z"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.07.023"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.12.014"},{"key":"e_1_2_11_201_1","first-page":"1383","article-title":"Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)","volume":"344","author":"Scandinavian Simvastatin Survival Study Group","year":"1994","journal-title":"Lancet"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017634.00171.24"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.6.688"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.7.871.32720"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.860"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.0030"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37486-1"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)42825-1"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13636-7"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200011000-00011"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040583"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.9.1194"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3791"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000108169.26553.D7"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-003-0066-2"},{"key":"e_1_2_11_216_1","first-page":"490","article-title":"Beyond cholesterol lowering: effect of statins on markers of cardiovascular disease","volume":"6","author":"Levy Y","year":"2004","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081620098"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340047031"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000068461.45784.2F"},{"key":"e_1_2_11_220_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20110118"},{"key":"e_1_2_11_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02400-4"},{"key":"e_1_2_11_222_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.24.3211"},{"key":"e_1_2_11_223_1","doi-asserted-by":"publisher","DOI":"10.4104\/pcrj.2011.00095"},{"key":"e_1_2_11_224_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00005309"},{"key":"e_1_2_11_225_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-012-0126-z"},{"key":"e_1_2_11_226_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.111.015230"},{"key":"e_1_2_11_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.02.005"},{"key":"e_1_2_11_228_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1601"},{"key":"e_1_2_11_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2008.03.010"},{"key":"e_1_2_11_230_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000145877.28811.82"},{"key":"e_1_2_11_231_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00041.2004"},{"key":"e_1_2_11_232_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1998.2765"},{"key":"e_1_2_11_233_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198502143120705"},{"key":"e_1_2_11_234_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.6.548"},{"key":"e_1_2_11_235_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000143476.93376.04"},{"key":"e_1_2_11_236_1","first-page":"F471","article-title":"Integrated actions of renal medullary prostaglandins in the control of water excretion","volume":"240","author":"Stokes JB","year":"1981","journal-title":"Am J Physiol"},{"key":"e_1_2_11_237_1","first-page":"F529","article-title":"Prostaglandin synthesis inhibition and the action of vasopressin: studies in man and rat","volume":"232","author":"Berl T","year":"1977","journal-title":"Am J Physiol"},{"key":"e_1_2_11_238_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005080854"},{"key":"e_1_2_11_239_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8688"},{"key":"e_1_2_11_240_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008121289"},{"key":"e_1_2_11_241_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900130106"},{"key":"e_1_2_11_242_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00247.2006"},{"key":"e_1_2_11_243_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2010.01983.x"},{"key":"e_1_2_11_244_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-118422"},{"key":"e_1_2_11_245_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602331103"},{"key":"e_1_2_11_246_1","first-page":"F506","article-title":"Effects of calcitonin on the renal concentrating mechanism","volume":"245","author":"Rouffignac C","year":"1983","journal-title":"Am J Physiol"},{"key":"e_1_2_11_247_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803074200"},{"key":"e_1_2_11_248_1","first-page":"2055","volume-title":"Schrier's diseases of the kidney","author":"Bichet DG","year":"2012"},{"key":"e_1_2_11_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60439-0"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12422","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T23:59:15Z","timestamp":1747439955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,16]]},"references-count":248,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/jcmm.12422"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12422","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,16]]}}}