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The recently identified telocytes (<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s) might participate in the maintenance of structural and functional integrity of oviduct tissue, but so far the involvement of <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content>s\u2010affected oviduct tissue and potential impact on fertility capacity remain unknown. By an integrated technique of haematoxylin and eosin staining, <jats:italic>in situ<\/jats:italic> immunohistochemistry and double\u2010labelled immunofluorescence staining and electron microscopy approach, <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s were studied in the autotransplantation <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2013<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rat model of EMs\u2010affected oviduct tissue and in sham control, respectively, together with determination of <jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> COX<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">LPO<\/jats:styled-content> and estradiol. <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s were found in perivascular connective tissue and smooth muscle bundles in sham oviduct, with typical ultrastructural features (a slender piriform\/spindle\/triangular cell body, and one or more extremely long prolongations, emerged from cell bodies and extend to various directions), and specific immunophenotype of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\u2010positive\/vimentin\u2010positive\/c\u2010kit\u2010negative. However, in EMs\u2010affected oviduct tissue (grade III), extensive ultrastructural damage (degeneration, discontinue, dissolution and destruction), significant decrease or loss of <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s and interstitial fibrosis were observed, together with elevated level of <jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> COX<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">LPO<\/jats:styled-content> and estradiol, thus suggestive of inflammation and ischaemia\u2010induced <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s damage. Based on <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s distribution and intercellular connections, we proposed that such damage might be involved in structural and functional abnormalities of oviduct, such as attenuated intercellular signalling and oviduct contractility, impaired immunoregulation and stem cell\u2010mediated tissue repair, 3\u2010D interstitial architectural derangement and tissue fibrosis. Therefore, <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s damage might provide a new explanation and potential target for <jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content>s\u2010induced tubal damage and fertility disorders.<\/jats:p>","DOI":"10.1111\/jcmm.12427","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T10:56:11Z","timestamp":1415703371000},"page":"452-462","source":"Crossref","is-referenced-by-count":55,"title":["Telocytes damage in endometriosis\u2010affected rat oviduct and potential impact on fertility"],"prefix":"10.1111","volume":"19","author":[{"given":"Xiao\u2010Jun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and 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