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Angiogenesis contributes to cardiac repair and functional recovery in post\u2010\n                    <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                    . Our previous study shows that apelin (\n                    <jats:styled-content style=\"fixed-case\">APLN<\/jats:styled-content>\n                    ) increases Sirtuin 3 (Sirt3) expression and ameliorates diabetic cardiomyopathy. In this study, we further investigated the direct role of Sirt3 in\n                    <jats:styled-content style=\"fixed-case\">APLN<\/jats:styled-content>\n                    \u2010induced angiogenesis in post\u2010\n                    <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                    model of diabetes. Wild\u2010type (\n                    <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>\n                    ) and Sirt3 knockout (Sirt3\n                    <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>\n                    ) mice were induced into diabetes by i.p. streptozotocin (\n                    <jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content>\n                    ).\n                    <jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content>\n                    mice were then subjected to\n                    <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                    followed by immediate intramyocardial injection with adenovirus\u2010apelin (Ad\u2010\n                    <jats:styled-content style=\"fixed-case\">APLN<\/jats:styled-content>\n                    ). Our studies showed that Sirt3 expression was significantly reduced in the hearts of\n                    <jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content>\n                    mice. Ad\u2010\n                    <jats:styled-content style=\"fixed-case\">APLN<\/jats:styled-content>\n                    treatment resulted in up\u2010regulation of Sirt3, angiopoietins\/Tie\u20102 and\n                    <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content>\n                    2 expression together with increased myocardial vascular densities in\n                    <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content>\n                    +\n                    <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                    mice, but these alterations were not observed in Sirt3\n                    <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content>\n                    +\n                    <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                    mice.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , overexpression of\n                    <jats:styled-content style=\"fixed-case\">APLN<\/jats:styled-content>\n                    increased Sirt3 expression and angiogenesis in endothelial progenitor cells (\n                    <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                    ) from\n                    <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>\n                    mice, but not in\n                    <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                    from Sirt3\n                    <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>\n                    mice.\n                    <jats:styled-content style=\"fixed-case\">APLN<\/jats:styled-content>\n                    gene therapy increases angiogenesis and improves cardiac functional recovery in diabetic hearts\n                    <jats:italic>via<\/jats:italic>\n                    up\u2010regulation of Sirt3 pathway.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12453","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T03:29:04Z","timestamp":1413257344000},"page":"53-61","source":"Crossref","is-referenced-by-count":71,"title":["Sirt3 is essential for apelin\u2010induced angiogenesis in post\u2010myocardial infarction of diabetes"],"prefix":"10.1111","volume":"19","author":[{"given":"Xuwei","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Mississippi Medical Center Jackson MS 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