{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:31:54Z","timestamp":1791919914429,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T00:00:00Z","timestamp":1412553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T00:00:00Z","timestamp":1412553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ulcerative colitis (\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    ) is characterized by chronic relapsing intestinal inflammation finally leading to extensive tissue fibrosis and resulting in a stiff colon unable to carry out peristalsis or to resorb fluids. Telocytes, a peculiar type of stromal cells, have been recently identified in the human gastrointestinal tract. Several roles have been proposed for telocytes, including mechanical support, intercellular signalling and modulation of intestinal motility. The aim of the present work was to investigate the presence and distribution of telocytes in colonic specimens from\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    patients compared with controls. Archival paraffin\u2010embedded samples of the left colon from\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    patients who underwent elective bowel resection and controls were collected. Tissue sections were stained with\n                    <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                    asson's trichrome to detect fibrosis. Telocytes were identified by\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    34 immunohistochemistry. In early fibrotic\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    cases, fibrosis affected the muscularis mucosae and submucosa, while the muscularis propria was spared. In advanced fibrotic\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    cases, fibrosis extended to affect the muscle layers and the myenteric plexus. Few telocytes were found in the muscularis mucosae and submucosa of both early and advanced fibrotic\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    colonic wall. In the muscle layers and myenteric plexus of early fibrotic\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    , telocytes were preserved in their distribution. In the muscularis propria of advanced fibrotic\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    , the network of telocytes was reduced or even completely absent around smooth muscle bundles and myenteric plexus ganglia, paralleling the loss of the network of interstitial cells of Cajal. In\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    , a loss of telocytes accompanies the fibrotic remodelling of the colonic wall and might contribute to colonic dysmotility.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12457","type":"journal-article","created":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T05:48:44Z","timestamp":1412574524000},"page":"62-73","source":"Crossref","is-referenced-by-count":102,"title":["Telocytes are reduced during fibrotic remodelling of the colonic wall in ulcerative colitis"],"prefix":"10.1111","volume":"19","author":[{"given":"Mirko","family":"Manetti","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine Section of Anatomy and Histology University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Rosa","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Section of Anatomy and Histology University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Messerini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Section of Surgery, Histopathology and Molecular Pathology University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Ibba\u2010Manneschi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Section of Anatomy and Histology University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0789-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2008.05.009"},{"key":"e_1_2_7_4_1","first-page":"1283","article-title":"Can we prevent, reduce or reverse intestinal fibrosis in IBD?","volume":"17","author":"Latella G","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320773"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000080"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90079-Z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e328332c977"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200605000-00008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01298.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i1.37"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01059.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/BMC.2011.039"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-416012-5.00011-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00461.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12134"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01119.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.23022"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-12-0369"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2005.tb00502.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01449.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12052"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12290"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12302"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01325.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00278"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2012.01580.x"},{"key":"e_1_2_7_28_1","first-page":"83","article-title":"The Tandem: telocytes \u2013 stem cells","volume":"5","author":"Popescu LM","year":"2011","journal-title":"Int J Biol Biomed Eng"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12177"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12228"},{"key":"e_1_2_7_31_1","first-page":"831","article-title":"CD34+ stromal cells\/fibroblasts\/fibrocytes\/telocytes as a tissue reserve and a principal source of mesenchymal cells. 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