{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:39:09Z","timestamp":1791405549146,"version":"4.3.3"},"reference-count":79,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81302168"],"award-info":[{"award-number":["No. 81302168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mesenchymal stem cells (\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    s) are a group of stem cells derived from the mesodermal mesenchyme.\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    s can be obtained from a variety of tissues, including bone marrow, umbilical cord tissue, umbilical cord blood, peripheral blood and adipose tissue. Under certain conditions,\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    s can differentiate into many cell types both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    , including hepatocytes. To date, four main strategies have been developed to induce the transdifferentiation of\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    s into hepatocytes: addition of chemical compounds and cytokines, genetic modification, adjustment of the micro\u2010environment and alteration of the physical parameters used for culturing\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    s. Although the phenomenon of transdifferentiation of\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    s into hepatocytes has been described, the detailed mechanism is far from clear. Generally, the mechanism is a cascade reaction whereby stimulating factors activate cellular signalling pathways, which in turn promote the production of transcription factors, leading to hepatic gene expression. Because\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    s can give rise to hepatocytes, they are promising to be used as a new treatment for liver dysfunction or as a bridge to liver transplantation. Numerous studies have confirmed the therapeutic effects of\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    s on hepatic fibrosis, cirrhosis and other liver diseases, which may be related to the differentiation of\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    s into functional hepatocytes. In addition to transdifferentiation into hepatocytes, when\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    s are used to treat liver disease, they may also inhibit hepatocellular apoptosis and secrete various bioactive molecules to promote liver regeneration. In this review, the capacity and molecular mechanism of\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    transdifferentiation, and the therapeutic effects of\n                    <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                    s on liver diseases are thoroughly discussed.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12482","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T04:46:02Z","timestamp":1419309962000},"page":"511-520","source":"Crossref","is-referenced-by-count":108,"title":["The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases"],"prefix":"10.1111","volume":"19","author":[{"given":"Wei\u2010hui","family":"Liu","sequence":"first","affiliation":[{"name":"General Surgery Center Chengdu Military General Hospital Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010qiang","family":"Song","sequence":"additional","affiliation":[{"name":"Experimental Medical Center Chengdu Military General Hospital Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010na","family":"Ren","sequence":"additional","affiliation":[{"name":"General Surgery Center Chengdu Military General Hospital Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010qiong","family":"Guo","sequence":"additional","affiliation":[{"name":"Nursing College Chengdu Medical School Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"General Surgery Center Chengdu Military General Hospital Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010xing","family":"Feng","sequence":"additional","affiliation":[{"name":"Experimental Medical Center Chengdu Military General Hospital Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010jun","family":"Tang","sequence":"additional","affiliation":[{"name":"General Surgery Center Chengdu Military General Hospital Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"Experimental Medical Center Chengdu Military General Hospital Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"e_1_2_11_2_1","article-title":"Challenges to liver transplantation and strategies to improve outcomes","author":"Dutkowski P","year":"2014","journal-title":"Gastroenterology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9540"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X680064"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.44"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368913X672046"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4161\/org.27879"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2013.12.006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X678292"},{"key":"e_1_2_11_10_1","first-page":"274","article-title":"Potential uses for cord blood mesenchymal stem cells","volume":"15","author":"Zarrabi M","year":"2014","journal-title":"Cell J"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt336"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-014-9718-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5754\/hge11220"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26975"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.154880"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704421104"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0342"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2010.04.003"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21704"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1681"},{"key":"e_1_2_11_21_1","first-page":"244","article-title":"In vitro differentiation of human bone marrow mesenchymal stem cells into hepatocyte\u2010like cells","volume":"14","author":"Pournasr B","year":"2011","journal-title":"Arch Iran Med"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0169"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1499-3872(12)60193-3"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2009.01.018"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21275"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2010.08.005"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl058"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2004-0176"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1042\/CBI20110016"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2009.05.007"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2170"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/860578"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.05.019"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.01.024"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2012.706706"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2010.00692.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.08.058"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000187716"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-010-9126-5"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6095-6"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22362"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50273"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1089769"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104133"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00187.2007"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-7-24"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209331"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20345"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21223"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06287.x"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.04.013"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200601018"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0572"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0168"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21301"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2013.02.013"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2012.0594"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1729"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0345"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1559"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-154138"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001332"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-074997"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12355"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12195"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1364"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00007.2005"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.4238\/2014.April.30.10"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04231.x"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000941"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22236"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.02.009"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/term"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.44"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.015"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2690"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06188"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12010"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12228"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.01.028"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12482","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.12482","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:09:59Z","timestamp":1696162199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,23]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/jcmm.12482"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12482","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,23]]}}}