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Research using rodent\n                    <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>\n                    models transgenic for mutant superoxide dismutase 1 (\n                    <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>\n                    1) has implicated that glial\u2013neuronal interactions play a major role in the destruction of motor neurons, but the generality of this mechanism is not clear as\n                    <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>\n                    1 mutations only account for less than 2% of all\n                    <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>\n                    cases. Recently, this hypothesis was backed up by observation of similar effects using astrocytes derived from post\u2010mortem spinal cord tissue of\n                    <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>\n                    patients which did not carry\n                    <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>\n                    1 mutations. However, such necropsy samples may not be easy to obtain and may not always yield viable cell cultures. Here, we have analysed olfactory mucosa (OM) cells, which can be easily isolated from living\n                    <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>\n                    patients. Disease\u2010specific changes observed when\n                    <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>\n                    OM cells were co\u2010cultured with human spinal cord neurons included decreased neuronal viability, aberrant neuronal morphology and altered glial inflammatory responses. Our results show the potential of OM cells as new cell models for\n                    <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12488","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T10:23:47Z","timestamp":1427365427000},"page":"1284-1295","source":"Crossref","is-referenced-by-count":9,"title":["Patient\u2010derived olfactory mucosa for study of the non\u2010neuronal contribution to amyotrophic lateral sclerosis pathology"],"prefix":"10.1111","volume":"19","author":[{"given":"Vega","family":"Garc\u00eda\u2010Escudero","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular Universidad Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (C.S.I.C.\u2010 U.A.M.) 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