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As inherent factors are not completely known \u2013\n                    <jats:italic>e.g<\/jats:italic>\n                    . age or family history, radiation exposure, benzene chemical exposure, certain viral exposures such as infection with the human T\u2010cell lymphoma\/leukaemia virus\u20101, as well as some inherited syndromes may raise the risk of\n                    <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\n                    \u2013 each\n                    <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\n                    patient may modify the susceptibility of therapy. Indeed, we consider these unknown inherent factors could be explained\n                    <jats:italic>via<\/jats:italic>\n                    coupling cytogenetics plus proteomics, especially when proteins are the ones which play function within cells. Innovative proteomics to\n                    <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\n                    therapy may help to understand the mechanism of drug resistance and toxicities, which in turn will provide some leads to improve\n                    <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\n                    management. Most important of these are shotgun proteomic strategies to unravel\n                    <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\n                    aberrant signalling networks. Some shotgun proteomic innovations and bioinformatic tools for\n                    <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\n                    therapies will be discussed. As network proteins are distinctive characteristics for\n                    <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\n                    patients, unrevealed by cytogenetics, those network proteins are currently an important source of novel therapeutic targets that emerge from shotgun proteomics. Indeed,\n                    <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\n                    evolution can be studied for each individual patient\n                    <jats:italic>via<\/jats:italic>\n                    oncoproteomics.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12507","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T21:45:43Z","timestamp":1419371143000},"page":"46-52","source":"Crossref","is-referenced-by-count":6,"title":["Application of oncoproteomics to aberrant signalling networks in changing the treatment paradigm in acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"19","author":[{"given":"Elena","family":"L\u00f3pez Villar","sequence":"first","affiliation":[{"name":"Department of Oncohematology and Pediatrics Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre Fudan University Zhongshan Hospital Shanghai China"},{"name":"Department of Respiratory Medicine Zhongshan Hospital Fudan University School of Medicine Shanghai Respiratory Research Institute Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Madero","sequence":"additional","affiliation":[{"name":"Department of Oncohematology and Pediatrics Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Queen Elizabeth Hospital Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12319"},{"key":"e_1_2_8_3_1","unstructured":"SeiterK(Department of Internal Medicine Division of Oncology\/Hematology New York Medical College member of the following medical societies: American Association for Cancer Research American College of Physicians and American Society of Hematology).Disclosure: Novartis Honoraria Speaking and teaching; Novartis Consulting fee Speaking and teaching; Ariad Honoraria Speaking and teaching; Celgene Honoraria Speaking and teaching. 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