{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:36:05Z","timestamp":1790706965321,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:00:00Z","timestamp":1426550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100528"],"award-info":[{"award-number":["81100528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ischaemic preconditioning (\n                    <jats:styled-content style=\"fixed-case\">IPC<\/jats:styled-content>\n                    ) attenuates acute kidney injury (\n                    <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n                    ) from renal ischaemia reperfusion. Renalase, an amine oxidase secreted by the proximal tubule, not only degrades circulating catecholamines but also protects against renal ischaemia reperfusion injury. Here, it has been suggested that the renoprotective effect of renal\n                    <jats:styled-content style=\"fixed-case\">IPC<\/jats:styled-content>\n                    is partly mediated by renalase. In a model of brief intermittent renal\n                    <jats:styled-content style=\"fixed-case\">IPC<\/jats:styled-content>\n                    , the increased cortex renalase expression was found to last for 48\u00a0hrs.\n                    <jats:styled-content style=\"fixed-case\">IPC<\/jats:styled-content>\n                    significantly reduced renal tubular inflammation, necrosis and oxidative stress following renal ischaemia reperfusion injury. Such effects were attenuated by blocking renalase with an anti\u2010renalase monoclonal antibody. We further demonstrated that renalase expression was up\u2010regulated by hypoxia\n                    <jats:italic>in vitro via<\/jats:italic>\n                    an hypoxia\u2010inducible factor (\n                    <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\n                    )\u20101\u03b1 mechanism. The\n                    <jats:styled-content style=\"fixed-case\">IPC<\/jats:styled-content>\n                    \u2010induced up\u2010regulation of renalase\n                    <jats:italic>in vivo<\/jats:italic>\n                    was also reduced by pre\u2010treatment with an\n                    <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\n                    \u20101\u03b1 inhibitor, 3\u2010(5\u2032\u2010Hydroxymethyl\u20102\u2032\u2010furyl)\u20101\u2010benzyl indazole. In summary, the renoprotective effect of\n                    <jats:styled-content style=\"fixed-case\">IPC<\/jats:styled-content>\n                    is partly dependent on the renalase expression, which may be triggered by hypoxia\n                    <jats:italic>via<\/jats:italic>\n                    an\n                    <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\n                    \u20101\u03b1 mechanism. Endogenous renalase shows potential as a therapeutic agent for the prevention and treatment of\n                    <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12527","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T05:43:13Z","timestamp":1426570993000},"page":"1400-1409","source":"Crossref","is-referenced-by-count":42,"title":["Renalase contributes to the renal protection of delayed\u00a0ischaemic preconditioning\n                    <i>via<\/i>\n                    the regulation of hypoxia\u2010inducible factor\u20101\u03b1"],"prefix":"10.1111","volume":"19","author":[{"given":"Feng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Jiao Tong University Affiliated First People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niansong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 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