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Telocyte (\n                    <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>\n                    ), a novel type of interstitial cell, has been identified in a variety of tissues and organs including liver.\n                    <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>\n                    s have been reported to be reduced in fibrotic areas after myocardial infarction, human interstitial wall's fibrotic remodelling caused either by ulcerative colitis or Crohn's disease, and skin of systemic sclerosis. However, the role of\n                    <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>\n                    s in human liver fibrosis remains unclear. Liver samples from human liver biopsy were collected. All samples were stained with Masson's trichrome to determine fibrosis.\n                    <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>\n                    s were identified by several immunofluorescence stainings including double labelling for\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    34 and c\u2010kit\/\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    117, or vimentin, or\n                    <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\n                    Receptor\u2010\u03b1, or \u03b2. We found that hepatic\n                    <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>\n                    s were significantly decreased by 27%\u201360% in human liver fibrosis, suggesting that loss of\n                    <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>\n                    s might lead to the altered organization of extracellular matrix and loss the control of fibroblast\/myofibroblast activity and favour the genesis of fibrosis. Adding\n                    <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>\n                    s might help to develop effective and targeted antifibrotic therapies for human liver fibrosis.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12542","type":"journal-article","created":{"date-parts":[[2015,2,8]],"date-time":"2015-02-08T20:37:02Z","timestamp":1423427822000},"page":"676-683","source":"Crossref","is-referenced-by-count":66,"title":["Telocytes in human liver fibrosis"],"prefix":"10.1111","volume":"19","author":[{"given":"Siyi","family":"Fu","sequence":"first","affiliation":[{"name":"Regeneration and Ageing Lab and Experimental Center of Life Sciences School of Life Science Shanghai University Shanghai China"},{"name":"Innovative Drug Research Center of Shanghai University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and 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