{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:28:36Z","timestamp":1775348916352,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270679"],"award-info":[{"award-number":["81270679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY12H04004"],"award-info":[{"award-number":["LY12H04004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute salpingitis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) is an inflammatory disease which causes severe damage to a subset of classically described cells lining in oviduct wall and contributes to interstitial fibrosis and fertility problems. Telocytes (<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s), a newly discovered peculiar type of stromal cells, have been identified in many organs, including oviduct, with proposed multiple potential bio\u2010functions. However, with recent increasing reports regarding <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s alterations in disease\u2010affected tissues, there is still lack of evidence about <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s involvement in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010affected oviduct tissues and potential pathophysiological roles. We presently identified normal <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s by their characteristic ultrastructural features and immunophenotype. However, in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010affected oviduct tissues, <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s displayed multiple ultrastructural damage both in cellular body and prolongations, with obvious loss of <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s and development of tissue fibrosis. Furthermore, <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s lose their interstitial 3\u2010D network connected by homocellular or heterocellular junctions between <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s and adjacent cells. And especially, <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s connected to the activated immunocytes (mononuclear cells, eosinophils) and affected local immune state (repression or activation). Meanwhile, massive neutrophils infiltration and overproduced Inducible Nitric Oxide Synthase (iNOS), <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102, suggested mechanism of inflammatory\u2010induced <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s damage. Consequently, <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s damage might contribute to <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010induced structural and reproductive functional abnormalities of oviduct, probably <jats:italic>via<\/jats:italic>: (<jats:italic>i<\/jats:italic>) substances, energy and functional insufficiency, presumably, <jats:italic>e.g<\/jats:italic>. <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>\u2010specific genetic material profiles, ion channels, cytoskeletal elements, Tps dynamics, <jats:italic>etc<\/jats:italic>., (<jats:italic>ii<\/jats:italic>) impaired <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s\u2010mediated multicellular signalling, such as homeostasis\/angiogenesis, tissue repair\/regeneration, neurotransmission, (<jats:italic>iii<\/jats:italic>) derangement of 3\u2010D network and impaired mechanical support for <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s\u2010mediated multicellular signals within the stromal compartment, consequently induced interstitial fibrosis, (<jats:italic>iv<\/jats:italic>) involvement in local inflammatory process\/ immunoregulation and possibly immune\u2010mediated early pregnancy failure.<\/jats:p>","DOI":"10.1111\/jcmm.12548","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T09:25:08Z","timestamp":1425633908000},"page":"1720-1728","source":"Crossref","is-referenced-by-count":46,"title":["Ultrastructure damage of oviduct telocytes in rat model of acute salpingitis"],"prefix":"10.1111","volume":"19","author":[{"given":"Jian","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Yang","sequence":"additional","affiliation":[{"name":"Lab Center Medical College of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong\u2010Ji","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1128\/iai.65.6.2094-2099.1997","article-title":"Pelvic inflammatory disease isolates of Neisseria gonorrhoeae are distinguished by C1q\u2010dependent virulence for newborn rats and by the sac\u20104 region","volume":"65","author":"Nowicki S","year":"1997","journal-title":"Infect Immun"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90407-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01059.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319467"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01060.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01129.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01133.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1229-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01330.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/MPA.0b013e31823fbded","article-title":"Telocytes in the interstitium of human exocrine pancreas: ultrastructural evidence","volume":"41","author":"Nicolescu MI","year":"2011","journal-title":"Pancreas"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-012-1333-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2012.01580.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.11.91"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2011.11.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00461.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2005.tb00387.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-188"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01504.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1389.022"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2012.01583.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1556\/APhysiol.98.2011.3.10"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2005.tb00376.x"},{"key":"e_1_2_7_24_1","first-page":"387","article-title":"Interstitial Cajal\u2010like cells of human Fallopian tube express estrogen and progesterone receptors","volume":"40","author":"Cretoiu SM","year":"2009","journal-title":"J Cell Mol Med"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12392"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2012.01582.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12111"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01404.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1515\/BMC.2011.039"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12028"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2012.01655.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12177"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12228"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12457"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12057"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12427"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1998.tb12908.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3767"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00117.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01119.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.23022"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12052"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12302"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12429"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12290"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12350"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12295"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2215-z"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1589-1"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12240"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-12-0369"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-014-1268-0"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12149"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00278"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.029"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12548","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12548","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.12548","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:53:54Z","timestamp":1696247634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,6]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/jcmm.12548"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12548","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,6]]}}}