{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:55:35Z","timestamp":1790787335126,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:00:00Z","timestamp":1426550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL102042"],"award-info":[{"award-number":["HL102042"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>\n \n Mitochondrial dysfunction plays an important role in obesity\u2010induced cardiac impairment.\n SIRT<\/jats:styled-content>\n 3 is a mitochondrial protein associated with increased human life span and metabolism. This study investigated the functional role of\n SIRT<\/jats:styled-content>\n 3 in obesity\u2010induced cardiac dysfunction. Wild\u2010type (\n WT<\/jats:styled-content>\n ) and\n SIRT<\/jats:styled-content>\n 3 knockout (\n KO<\/jats:styled-content>\n ) mice were fed a normal diet (\n ND<\/jats:styled-content>\n ) or high\u2010fat diet (\n HFD<\/jats:styled-content>\n ) for 16\u00a0weeks. Body weight, fasting glucose levels, reactive oxygen species (\n ROS<\/jats:styled-content>\n ) levels, myocardial capillary density, cardiac function and expression of hypoxia\u2010inducible factor (\n HIF<\/jats:styled-content>\n )\u20101\u03b1\/\u20102\u03b1 were assessed.\n HFD<\/jats:styled-content>\n resulted in a significant reduction in\n SIRT<\/jats:styled-content>\n 3 expression in the heart. Both\n HFD<\/jats:styled-content>\n and\n SIRT<\/jats:styled-content>\n 3\n KO<\/jats:styled-content>\n mice showed increased\n ROS<\/jats:styled-content>\n formation, impaired\n HIF<\/jats:styled-content>\n signalling and reduced capillary density in the heart.\n HFD<\/jats:styled-content>\n induced cardiac hypertrophy and impaired cardiac function.\n SIRT<\/jats:styled-content>\n 3\n KO<\/jats:styled-content>\n mice fed\n HFD<\/jats:styled-content>\n showed greater\n ROS<\/jats:styled-content>\n production and a further reduction in cardiac function compared to\n SIRT<\/jats:styled-content>\n 3\n KO<\/jats:styled-content>\n mice on\n ND<\/jats:styled-content>\n . Thus, the adverse effects of\n HFD<\/jats:styled-content>\n on cardiac function were not attributable to\n SIRT<\/jats:styled-content>\n 3 loss alone. However,\n HFD<\/jats:styled-content>\n did not further reduce capillary density in\n SIRT<\/jats:styled-content>\n 3\n KO<\/jats:styled-content>\n hearts, implicating\n SIRT<\/jats:styled-content>\n 3 loss in\n HFD<\/jats:styled-content>\n \u2010induced capillary rarefaction. Our study demonstrates the importance of\n SIRT<\/jats:styled-content>\n 3 in preserving heart function and capillary density in the setting of obesity. Thus,\n SIRT<\/jats:styled-content>\n 3 may be a potential therapeutic target for obesity\u2010induced heart failure.\n <\/jats:p>","DOI":"10.1111\/jcmm.12556","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T05:35:00Z","timestamp":1426570500000},"page":"1847-1856","source":"Crossref","is-referenced-by-count":120,"title":["High\u2010fat diet induces cardiac remodelling and dysfunction: assessment of the role played by\n SIRT<\/scp>\n 3 loss"],"prefix":"10.1111","volume":"19","author":[{"given":"Heng","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology The University of Mississippi Medical Center, School of Medicine Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Ramana","family":"Vaka","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology The University of Mississippi Medical Center, School of Medicine Jackson MS 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