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The regenerative potential of <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>s from dog hearts has yet to be tested. Here, we show that canine <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>s can be produced from adult dog hearts. These cells display similar phenotypes in comparison to previously studied <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>s derived from rodents and human beings. Canine <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>s can differentiate into cardiomyocytes, smooth muscle cells and endothelial cells <jats:italic>in vitro<\/jats:italic>. In addition, conditioned media from canine <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>s promote angiogenesis but inhibit cardiomyocyte death. In a doxorubicin\u2010induced mouse model of dilated cardiomyopathy (<jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>), intravenous infusion of canine <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>s improves cardiac function and decreases cardiac fibrosis. Histology revealed that injected canine <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>s engraft in the mouse heart and increase capillary density. Out study demonstrates the regenerative potential of canine <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>s in a mouse model of <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.12585","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T06:16:29Z","timestamp":1428560189000},"page":"1805-1813","source":"Crossref","is-referenced-by-count":23,"title":["Cardiac regenerative potential of cardiosphere\u2010derived cells from adult dog hearts"],"prefix":"10.1111","volume":"19","author":[{"given":"Michael Taylor","family":"Hensley","sequence":"first","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Keene","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Meurs","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"},{"name":"Center for Comparative Medicine and Translational Researches North Carolina State University Raleigh NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junnan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"},{"name":"Department of Cardiology First Affiliated Hospital College of Medicine Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zegen","family":"Wang","sequence":"additional","affiliation":[{"name":"The Cyrus Tang Hematology Center Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Caranasos","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Piedrahita","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"},{"name":"Center for Comparative Medicine and Translational Researches North Carolina State University Raleigh NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao\u2010Sheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology Atomic Bomb Disease Institute Nagasaki University Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"},{"name":"Center for Comparative Medicine and Translational Researches North Carolina State University Raleigh NC USA"},{"name":"The Cyrus Tang Hematology Center Soochow University Suzhou China"},{"name":"Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012559"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368911X627381"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1184"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007195"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.049"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.532"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.029"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.042598"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201737"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.655209"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000147315.71699.51"},{"key":"e_1_2_7_13_1","unstructured":"GiacomelloA MessinaE BattagliaM et\u00a0al.Method for the isolation and expansion of cardiac stem cells from biopsy. 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