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The number, distribution and ultrastructure of <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s were recently shown to be affected in systemic scleroderma. Psoriasis is a common inflammatory skin condition (estimated to affect about 0.1\u201311.8% of population), a keratinization disorder on a genetic background. In psoriasis, the dermis contribution to pathogenesis is frequently eclipsed by remarkable epidermal phenomena. Because of the particular distribution of <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s around blood vessels, we have investigated <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s in the dermis of patients with psoriasis vulgaris using immunohistochemistry (<jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content>), immunofluorescence (<jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>), and transmission electron microscopy (<jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> revealed that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\/<jats:styled-content style=\"fixed-case\">PDGFR<\/jats:styled-content>\u03b1\u2010positive <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s are present in human papillary dermis. More <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s were present in the dermis of uninvolved skin and treated skin than in psoriatic dermis. In uninvolved skin, <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content> revealed <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s with typical ultrastructural features being involved in a 3D interstitial network in close vicinity to blood vessels in contact with immunoreactive cells in normal and treated skin. In contrast, the number of <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s was significantly decreased in psoriatic plaque. The remaining <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s demonstrated multiple degenerative features: apoptosis, membrane disintegration, cytoplasm fragmentation and nuclear extrusion. We also found changes in the phenotype of vascular smooth muscle cells in small blood vessels that lost the protective envelope formed by <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s. Therefore, impaired <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s could be a \u2018missed\u2019 trigger for the characteristic vascular pathology in psoriasis. Our data explain the mechanism of Auspitz's sign, the most pathognomonic clinical sign of psoriasis vulgaris. This study offers new insights on the cellularity of psoriatic lesions and we suggest that <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s should be considered new cellular targets in forthcoming therapies.<\/jats:p>","DOI":"10.1111\/jcmm.12601","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T03:01:00Z","timestamp":1432090860000},"page":"1504-1519","source":"Crossref","is-referenced-by-count":60,"title":["Telocyte dynamics in psoriasis"],"prefix":"10.1111","volume":"19","author":[{"given":"C.G.","family":"Manole","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Histology \u2018Carol Davila\u2019 University of Medicine and Pharmacy Bucharest Romania"},{"name":"Laboratory of Ultrastructural Research \u2018Victor Babe\u015f\u2019 National Institute of Pathology Bucharest 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