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Pridopidine is a new dopaminergic stabilizer, recently developed for the treatment of motor symptoms associated with\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    . The therapeutic effect of pridopidine in patients with\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    has been determined in two double\u2010blind randomized clinical trials, however, whether pridopidine exerts neuroprotection remains to be addressed. The main goal of this study was to define the potential neuroprotective effect of pridopidine, in\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    and\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    models, thus providing evidence that might support a potential disease\u2010modifying action of the drug and possibly clarifying other aspects of pridopidine mode\u2010of\u2010action. Our data corroborated the hypothesis of neuroprotective action of pridopidine in\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    experimental models. Administration of pridopidine protected cells from apoptosis, and resulted in highly improved motor performance in R6\/2 mice. The anti\u2010apoptotic effect observed in the\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    system highlighted neuroprotective properties of the drug, and advanced the idea of sigma\u20101\u2010receptor as an additional molecular target implicated in the mechanism of action of pridopidine. Coherent with protective effects, pridopidine\u2010mediated beneficial effects in R6\/2 mice were associated with an increased expression of pro\u2010survival and neurostimulatory molecules, such as brain derived neurotrophic factor and\n                    <jats:styled-content style=\"fixed-case\">DARPP<\/jats:styled-content>\n                    32, and with a reduction in the size of mHtt aggregates in striatal tissues. Taken together, these findings support the theory of pridopidine as molecule with disease\u2010modifying properties in\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    and advance the idea of a valuable therapeutic strategy for effectively treating the disease.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12604","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T02:45:34Z","timestamp":1434941134000},"page":"2540-2548","source":"Crossref","is-referenced-by-count":72,"title":["Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6\/2 mouse model"],"prefix":"10.1111","volume":"19","author":[{"given":"Ferdinando","family":"Squitieri","sequence":"first","affiliation":[{"name":"IRCCS Neuromed Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Di 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