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Double staining for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\/<jats:styled-content style=\"fixed-case\">PDGFR<\/jats:styled-content>\u2010\u03b2 (Platelet\u2010derived growth factor receptor \u03b2) or <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\/Vimentin is considered to be critical for <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content> phenotyping. It has recently been proposed that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\/<jats:styled-content style=\"fixed-case\">PDGFR<\/jats:styled-content>\u2010\u03b1 (Platelet\u2010derived growth factor receptor \u03b1) is actually a specific marker for <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s including cardiac <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s although the direct evidence is still lacking. Here, we showed that cardiac <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s were double positive for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\/<jats:styled-content style=\"fixed-case\">PDGFR<\/jats:styled-content>\u2010\u03b1 in primary culture. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\/<jats:styled-content style=\"fixed-case\">PDGFR<\/jats:styled-content>\u2010\u03b1 positive cells (putative cardiac <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s) also existed in mice ventricle and human cardiac valves including mitral valve, tricuspid valve and aortic valve. Over 87% of cells in a <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>\u2010enriched culture of rat cardiac interstitial cells were positive for <jats:styled-content style=\"fixed-case\">PDGFR<\/jats:styled-content>\u2010\u03b1, while <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\/<jats:styled-content style=\"fixed-case\">PDGFR<\/jats:styled-content>\u2010\u03b1 double positive cells accounted for 30.25% of the whole cell population. We show that cardiac <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s are double positive for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\/<jats:styled-content style=\"fixed-case\">PDGFR<\/jats:styled-content>\u2010\u03b1. Better understanding of the immunocytochemical phenotypes of cardiac <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s might help using cardiac <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>s as a novel source in cardiac repair.<\/jats:p>","DOI":"10.1111\/jcmm.12615","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T07:43:04Z","timestamp":1434526984000},"page":"2036-2042","source":"Crossref","is-referenced-by-count":78,"title":["Cardiac telocytes are double positive for <scp>CD<\/scp>34\/<scp>PDGFR<\/scp>\u2010\u03b1"],"prefix":"10.1111","volume":"19","author":[{"given":"Qiulian","family":"Zhou","sequence":"first","affiliation":[{"name":"Regeneration and Ageing Lab Experimental Center of Life Sciences School of Life Science Shanghai University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of 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