{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:41:21Z","timestamp":1696228881895},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T00:00:00Z","timestamp":1435017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transposition of great arteries (<jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>) is a common congenital heart disease. Left ventricle (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) is rapidly regressing and pulmonary artery banding (<jats:styled-content style=\"fixed-case\">PAB<\/jats:styled-content>) is utilized to retrain the undeveloped <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>. Hence, it offered a unique human disease model to investigate the process of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> hypertrophy under pressure overload. Eight late referred children with <jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content> were enrolled. The plasma was collected at the 30\u00a0min. before and 48\u00a0hrs after <jats:styled-content style=\"fixed-case\">PAB<\/jats:styled-content>, and 25 proteins were identified as having significant change in proteomic analysis. Transferrin (<jats:styled-content style=\"fixed-case\">TF<\/jats:styled-content>) and ceruloplasmin were then confirmed. After 48\u00a0hrs incubation with <jats:styled-content style=\"fixed-case\">TF<\/jats:styled-content>, the size of human induced pluripotent stem cell\u2010derived cardiomyocytes increased by two times as large as control. Meanwhile, protein synthesis and the expression of natriuretic peptide precursor A and B were significantly enhanced. <jats:styled-content style=\"fixed-case\">TF<\/jats:styled-content> treatment also activated both extracellular signal\u2010regulated kinase 1\/2 and activated protein kinase singling pathways. Our data provided a link to molecular components and pathways that might be involved in <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> retraining. <jats:styled-content style=\"fixed-case\">TF<\/jats:styled-content> severed as the carrier to delivery irons, and could directly stimulate cardiomyocytes hypertrophy. <jats:styled-content style=\"fixed-case\">TF<\/jats:styled-content> administration may hold therapeutic potential for the biological <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> retraining.<\/jats:p>","DOI":"10.1111\/jcmm.12627","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T07:19:35Z","timestamp":1435043975000},"page":"2423-2431","source":"Crossref","is-referenced-by-count":3,"title":["Role of augmented transferrin during the retraining for undeveloped left ventricle"],"prefix":"10.1111","volume":"19","author":[{"given":"Wei","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing China"},{"name":"Center for Pediatric Cardiac Surgery and Research Center for Cardiac Regenerative Medicine Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihe","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing China"},{"name":"Department of Thoracic Surgery 1st Affiliated Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongquan","family":"Ying","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoujun","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Pediatric Cardiac Surgery and Research Center for Cardiac Regenerative Medicine Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengshou","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing China"},{"name":"Center for Pediatric Cardiac Surgery and Research Center for Cardiac Regenerative Medicine Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing China"},{"name":"Center for Pediatric Cardiac Surgery and Research Center for Cardiac Regenerative Medicine Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.09.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6018.1112"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.09.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt105"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.150"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121371"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1934654100"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12064"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v6.i6.478"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.2.339"},{"key":"e_1_2_7_14_1","first-page":"I203","article-title":"Rapid, two\u2010stage arterial switch for transposition of the great arteries and intact ventricular septum beyond the neonatal period","volume":"80","author":"Jonas RA","year":"1989","journal-title":"Circulation"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr130"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.08.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.05.059"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2462"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2010.11.007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304926200"},{"key":"e_1_2_7_21_1","first-page":"427","article-title":"Fibrillation of transferrin","volume":"2012","author":"Booyjzsen C","year":"1820","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12356"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2012.04.007"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"14873","DOI":"10.1016\/S0021-9258(18)98556-X","article-title":"Identification of transferrin as a progression factor for ML\u20101 human myeloblastic leukemia cell differentiation","volume":"266","author":"Denstman S","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.01.009"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2009.117"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12627","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.12627","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T22:44:47Z","timestamp":1696200287000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,23]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/jcmm.12627"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12627","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,23]]}}}