{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:38:00Z","timestamp":1791175080849,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T00:00:00Z","timestamp":1439164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T00:00:00Z","timestamp":1439164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Abstract<\/jats:title>\n \n Regeneration of the lung airway epithelium after injury has been extensively studied. In contrast, analysis of its turnover in healthy adulthood has received little attention. In the classical view, this epithelium is maintained in the steady\u2010state by the infrequent proliferation of basal or Clara cells. The intermediate filament protein nestin was initially identified as a marker for neural stem cells, but its expression has also been detected in other stem cells. Lungs from\n CD<\/jats:styled-content>\n 1 mice at the age of 2, 6, 12, 18 or 24\u00a0months were fixed in neutral\u2010buffered formalin and paraffin\u2010embedded. Nestin expression was examined by an immunohistochemical peroxidase\u2010based method. Nestin\u2010positive cells were detected in perivascular areas and in connective tissue that were in close proximity of the airway epithelium. Also, nestin\u2010positive cells were found among the cells lining the airway epithelium. These findings\n suggest<\/jats:bold>\n that nestin\u2010positive stem cells circulate in the bloodstream, transmigrate through blood vessels and localize in the lung airway epithelium to participate in its turnover. We previously reported the existence of similar cells able to differentiate into lung chondrocytes. Thus, the stem cell reported here\n might be<\/jats:bold>\n a bone marrow\u2010derived mesenchymal stem cell (\n BMDMSC<\/jats:styled-content>\n ) able to generate several types of lung tissues. In conclusion, our findings indicate that there exist a\n BMDMSC<\/jats:styled-content>\n in healthy adulthood that participates in the turnover of the lung airway epithelium. These findings may improve our knowledge about the lung stem cell biology and also provide novel approaches to therapy for devastating pulmonary diseases.\n <\/jats:p>","DOI":"10.1111\/jcmm.12653","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T05:12:52Z","timestamp":1439183572000},"page":"2679-2681","source":"Crossref","is-referenced-by-count":8,"title":["Detection of a novel stem cell probably involved in normal turnover of the lung airway epithelium"],"prefix":"10.1111","volume":"19","author":[{"given":"Marta","family":"Ortega\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Pathology School of Medicine Autonomous University of Nuevo Leon Monterrey Nuevo Leon Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Rodr\u00edguez\u2010Flores","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Autonomous University of Nuevo Leon Monterrey Nuevo Leon Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"de\u2010la\u2010Garza\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Embryology School of Medicine Autonomous University of Nuevo Leon Monterrey Nuevo Leon Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Ancer\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Autonomous University of Nuevo Leon Monterrey Nuevo Leon Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Jaramillo\u2010Rangel","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Autonomous University of Nuevo Leon Monterrey Nuevo Leon 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