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However, the effects of <jats:styled-content style=\"fixed-case\">DGAT<\/jats:styled-content>1 silencing in the human liver have not been elucidated. To investigate the effects of <jats:styled-content style=\"fixed-case\">DGAT<\/jats:styled-content>1 silencing in human liver cells, we compared the cellular behaviours of <jats:styled-content style=\"fixed-case\">DGAT<\/jats:styled-content>1\u2010deficient Huh\u20107.5 cell lines with those of control Huh\u20107.5 cells. <jats:styled-content style=\"fixed-case\">DGAT<\/jats:styled-content>1\u2010deficient cells acquired dedifferentiated and stem cell\u2010like characteristics, such as formation of aggregates in the presence of high levels of growth factors, high proliferation rates and loss of albumin secretion. In relation to aggregate formation, the expression level of various adhesion molecules was significantly altered in <jats:styled-content style=\"fixed-case\">DGAT<\/jats:styled-content>1\u2010deficient cells. Microarray data analysis and immunostaining of patient tissue samples clearly showed decreased expression levels of <jats:styled-content style=\"fixed-case\">DGAT<\/jats:styled-content>1 and integrin \u03b21 in patients who have nodular cirrhosis without fatty degeneration.<\/jats:p>","DOI":"10.1111\/jcmm.12685","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T19:13:03Z","timestamp":1445627583000},"page":"38-47","source":"Crossref","is-referenced-by-count":3,"title":["Prolonged silencing of diacylglycerol acyltransferase\u20101 induces a dedifferentiated phenotype in human liver cells"],"prefix":"10.1111","volume":"20","author":[{"given":"Soyoung","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Bio and Brain Engineering KAIST Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pil Soo","family":"Sung","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Infectious 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