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Angiotensin1\u20107 [Ang\u2010(1\u20107)] is a newly established bioactive peptide of renin\u2013angiotensin system, which has been shown to counteract the deleterious effects of Ang II. However, the precise impact of Ang\u2010(1\u20107) on Ang II\u2010induced cardiomyocyte autophagy remained essentially elusive. The aim of the present study was to examine if Ang\u2010(1\u20107) inhibits Ang II\u2010induced autophagy and the underlying mechanism involved. Cultured neonatal rat cardiomyocytes were exposed to Ang II for 48\u00a0hrs while mice were infused with Ang II for 4\u00a0weeks to induce models of cardiac hypertrophy <jats:italic>in\u00a0vitro<\/jats:italic> and <jats:italic>in\u00a0vivo<\/jats:italic>. <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3b\u2010II and p62, markers of autophagy, expression were significantly elevated in cardiomyocytes, suggesting the presence of autophagy accompanying cardiac hypertrophy in response to Ang II treatment. Besides, Ang II induced oxidative stress, manifesting as an increase in malondialdehyde production and a decrease in superoxide dismutase activity. Ang\u2010(1\u20107) significantly retarded hypertrophy, autophagy and oxidative stress in the heart. Furthermore, a role of Mas receptor in Ang\u2010(1\u20107)\u2010mediated action was assessed using A779 peptide, a selective Mas receptor antagonist. The beneficial responses of Ang\u2010(1\u20107) on cardiac remodelling, autophagy and oxidative stress were mitigated by A779. Taken together, these result indicated that Mas receptor mediates cardioprotection of angiotensin\u2010(1\u20107) against Ang II\u2010induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress.<\/jats:p>","DOI":"10.1111\/jcmm.12687","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T09:53:12Z","timestamp":1446198792000},"page":"48-57","source":"Crossref","is-referenced-by-count":68,"title":["Mas receptor mediates cardioprotection of angiotensin\u2010(1\u20107) against Angiotensin II\u2010induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress"],"prefix":"10.1111","volume":"20","author":[{"given":"Li","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine East Hospital Tongji University School of Medicine Shanghai 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