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In this study, we used <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content><jats:sub>35\u201055<\/jats:sub>\u2010induced experimental autoimmune encephalomyelitis (<jats:styled-content style=\"fixed-case\">EAE<\/jats:styled-content>), a model of human <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>, to assess the production of catalytically active immunoglobulin G (IgG) antibodies or abzymes which have been shown to be present in sera of patients with several autoimmune diseases. Here, we show that IgGs from the sera of control C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice are catalytically inactive. During development of <jats:styled-content style=\"fixed-case\">EAE<\/jats:styled-content>, a specific reorganization of the immune system of mice occurred leading to a condition which was associated with the generation of catalytically active IgGs hydrolysing <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, myelin basic protein (<jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content> which was associated with increased proteinuria, changes in differentiation of mice bone marrow hematopoietic stem cells (<jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s) and an increase in proliferation of lymphocytes in bone marrow, spleen and thymus as well as a significant suppression of cell apoptosis in these organs. The strongest alterations were found in the early disease phase (18\u201324 days after immunization) and were less pronounced in later <jats:styled-content style=\"fixed-case\">EAE<\/jats:styled-content> stages (40 days after <jats:styled-content style=\"fixed-case\">EAE<\/jats:styled-content> induction). We conclude that a significant increase in <jats:styled-content style=\"fixed-case\">DN<\/jats:styled-content>ase and proteolytic activities of antibodies may be considered the earliest statistically significant marker of <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">EAE<\/jats:styled-content> in mice. The possible differences in immune system reorganizations during preclinical phases of the disease, acute and late <jats:styled-content style=\"fixed-case\">EAE<\/jats:styled-content>, leading to production of different auto\u2010antibodies and abzymes as well other changes are discussed.<\/jats:p>","DOI":"10.1111\/jcmm.12704","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T19:15:34Z","timestamp":1445627734000},"page":"81-94","source":"Crossref","is-referenced-by-count":38,"title":["Changes in different parameters, lymphocyte proliferation and hematopoietic progenitor colony formation in <scp>EAE<\/scp> mice treated with myelin oligodendrocyte glycoprotein"],"prefix":"10.1111","volume":"20","author":[{"given":"Vasilii B.","family":"Doronin","sequence":"first","affiliation":[{"name":"Novosibirsk Medical University Ministry of Public Health of Russian Federation Novosibirsk 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