{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:46:35Z","timestamp":1783651595280,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T00:00:00Z","timestamp":1446076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia","doi-asserted-by":"publisher","award":["2012MS1152"],"award-info":[{"award-number":["2012MS1152"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000294"],"award-info":[{"award-number":["81000294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370917"],"award-info":[{"award-number":["81370917"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300311"],"award-info":[{"award-number":["81300311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81360212"],"award-info":[{"award-number":["81360212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100993"],"award-info":[{"award-number":["81100993"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471045"],"award-info":[{"award-number":["81471045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["Y14H070033"],"award-info":[{"award-number":["Y14H070033"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ13H280002"],"award-info":[{"award-number":["LQ13H280002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To explore the effects of celecoxib on pressure overload\u2010induced cardiac hypertrophy (<jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content>), cardiac dysfunction and explore the possible protective mechanisms. We surgically created abdominal aortic constrictions (<jats:styled-content style=\"fixed-case\">AAC<\/jats:styled-content>) in rats to induce <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content>. Rats with <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> symptoms at 4 weeks after surgery were treated with celecoxib [2 mg\/100 g body\u2010weight(BW)] daily for either 2 or 4 weeks. Survival rate, blood pressure and cardiac function were evaluated after celecoxib treatment. Animals were killed, and cardiac tissue was examined for morphological changes, cardiomyocyte apoptosis, fibrosis, inflammation and oxidative stress. Four weeks after <jats:styled-content style=\"fixed-case\">AAC<\/jats:styled-content>, rats had significantly higher systolic, diastolic and mean blood pressure, greater heart weight and enlarged cardiomyocytes, which were associated with cardiac dysfunction. Thus, the <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> model was successfully established. Two weeks later, animals had impaired cardiac function and histopathological abnormalities including enlarged cardiomyocytes and cardiac fibrosis, which were exacerbated 2 weeks later. However, these pathological changes were remarkably prevented by the treatment of celecoxib, independent of preventing hypertension. Mechanistic studies revealed that celecoxib\u2010induced cardiac protection against <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> and cardiac dysfunction was due to inhibition of apoptosis <jats:italic>via<\/jats:italic> the murine double mimute 2\/P53 pathway, inhibition of inflammation <jats:italic>via<\/jats:italic> the <jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB pathway and inhibition of oxidative stress <jats:italic>via<\/jats:italic> increases in nuclear factor E2\u2010related factor\u20102\u2010mediated gene expression of multiple antioxidants. Celecoxib suppresses pressure overload\u2010induced <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> by reducing apoptosis, inflammation and oxidative stress.<\/jats:p>","DOI":"10.1111\/jcmm.12709","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T14:38:50Z","timestamp":1446129530000},"page":"116-127","source":"Crossref","is-referenced-by-count":53,"title":["Celecoxib prevents pressure overload\u2010induced cardiac hypertrophy and dysfunction by inhibiting inflammation, apoptosis and oxidative stress"],"prefix":"10.1111","volume":"20","author":[{"given":"Chi","family":"Zhang","sequence":"first","affiliation":[{"name":"Ruian Center of the Chinese\u2010American Research Institute for Diabetic Complications Wenzhou Medical University Wenzhou Zhejiang China"},{"name":"School of Pharmaceutical Science Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Hui\u2010Long\u2010Guan Hospital Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Kang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Si","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Su","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Xin","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Hao","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lechu","family":"Yu","sequence":"additional","affiliation":[{"name":"Ruian Center of the Chinese\u2010American Research Institute for Diabetic Complications Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhong","family":"Xu","sequence":"additional","affiliation":[{"name":"The Affiliated Wenling Hospital of Wenzhou Medial University Wenling Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlong","family":"Liu","sequence":"additional","affiliation":[{"name":"Ruian Center of the Chinese\u2010American Research Institute for Diabetic Complications Wenzhou Medical University Wenzhou Zhejiang China"},{"name":"School of Pharmaceutical Science Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Xue","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2014.36"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.10R31FM"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.02.020"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350091"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4416"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.144"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2011.08.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000028755.86521.11"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.02.013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020706316429"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.208199"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/ajh\/2.12.931","article-title":"Myocardial collagen remodeling in pressure overload hypertrophy. A case for interstitial heart disease","volume":"2","author":"Weber KT","year":"1989","journal-title":"Am J Hypertens"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816070-00018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2012.666650"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2008.44.9.1251573"},{"key":"e_1_2_9_17_1","first-page":"66","article-title":"The future of traditional nonsteroidal antiinflammatory drugs and cyclooxygenase\u20102 inhibitors in the treatment of inflammation and pain","volume":"57","author":"Sciulli MG","year":"2005","journal-title":"Pharmacol Rep"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdp.2003.12.005"},{"key":"e_1_2_9_19_1","first-page":"285","article-title":"Celecoxib mitigates cigarette smoke induced oxidative stress in mice","volume":"47","author":"Koul A","year":"2010","journal-title":"Indian J Biochem Biophys"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2005.11.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.01.012"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22169"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.179325"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.01.017"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2010.05405.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200204000-00036"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.02.041"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.07.026"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.034"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00452.2009"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092574"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.019"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.022"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00124.2004"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142243"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.92"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00852.2006"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.115006"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-010-9168-8"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76628"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-253823"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.05.017"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2013.00033"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000211746.78454.50"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq109"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-014-1328-7"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.7556\/jaoa.1999.99.11.S13"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.8.11.1719"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.suppl_2.21"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2014.07.006"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3232-6"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-010-0586-6"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.4.6.1005"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00428.2004"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-199803000-00011"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1385\/CT:3:3:219"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.679597"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9131-7"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1829"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1505"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010811414206"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.11.020"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-014-0200-5"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12709","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.12709","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T11:24:23Z","timestamp":1696505063000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,29]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/jcmm.12709"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12709","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,29]]}}}