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A total of 2 \u00d7 10<jats:sup>5<\/jats:sup> progenitors, cardiomyocytes or cell\u2010free saline were injected into peri\u2010infarcted anterior free wall. Sham\u2010operated animals received no injection. Myocardial function was assessed at 2\u2010week and 4\u2010week post\u2010infarction by using echocardiography and pressure\u2010volume catheterization. Early myocardial remodelling was observed at 2\u2010week with echocardiography derived stroke volume (<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>) in saline (20.45 \u00b1 7.36 \u03bcl, <jats:italic>P<\/jats:italic> &lt; 0.05) and cardiomyocyte (19.52 \u00b1 3.97 \u03bcl, <jats:italic>P<\/jats:italic> &lt; 0.05) groups, but not in progenitor group (25.65 \u00b1 3.61 \u03bcl), significantly deteriorated as compared to sham control group (28.41 \u00b1 4.41 \u03bcl). Consistently, pressure<jats:bold>\u2013<\/jats:bold>volume haemodynamic measurements showed worsening chamber dilation in saline (<jats:styled-content style=\"fixed-case\">EDV<\/jats:styled-content>: 23.24 \u00b1 5.01 \u03bcl, <jats:italic>P<\/jats:italic> &lt; 0.05; <jats:styled-content style=\"fixed-case\">ESV<\/jats:styled-content>: 17.08 \u00b1 5.82 \u03bcl, <jats:italic>P<\/jats:italic> &lt; 0.05) and cardiomyocyte (<jats:styled-content style=\"fixed-case\">EDV<\/jats:styled-content>: 26.45 \u00b1 5.69 \u03bcl, <jats:italic>P<\/jats:italic> &lt; 0.05; <jats:styled-content style=\"fixed-case\">ESV<\/jats:styled-content>: 18.03 \u00b1 6.58 \u03bcl, <jats:italic>P<\/jats:italic> &lt; 0.05) groups by 4\u2010week post\u2010infarction as compared to control (<jats:styled-content style=\"fixed-case\">EDV<\/jats:styled-content>: 15.26 \u00b1 2.96 \u03bcl; <jats:styled-content style=\"fixed-case\">ESV<\/jats:styled-content>: 8.41 \u00b1 2.94 \u03bcl). In contrast, cardiac progenitors (<jats:styled-content style=\"fixed-case\">EDV<\/jats:styled-content>: 20.09 \u00b1 7.76 \u03bcl; <jats:styled-content style=\"fixed-case\">ESV<\/jats:styled-content>: 13.98 \u00b1 6.74 \u03bcl) persistently protected chamber geometry against negative cardiac remodelling. Similarly, as compared to sham control (54.64 \u00b1 11.37%), <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> ejection fraction was preserved in progenitor group from 2\u2010(38.68 \u00b1 7.34%) to 4\u2010week (39.56 \u00b1 13.26%) while cardiomyocyte (36.52 \u00b1 11.39%, <jats:italic>P<\/jats:italic> &lt; 0.05) and saline (35.34 \u00b1 11.86%, <jats:italic>P<\/jats:italic> &lt; 0.05) groups deteriorated early at 2\u2010week. Improvements of myocardial function in the progenitor group corresponded to increased vascularization (16.12 \u00b1 1.49\/mm<jats:sup>2<\/jats:sup> to 25.48 \u00b1 2.08\/mm<jats:sup>2<\/jats:sup> myocardial tissue, <jats:italic>P<\/jats:italic> &lt; 0.05) and coincided with augmented networking of cardiac telocytes in the interstitial space of infarcted zone.<\/jats:p>","DOI":"10.1111\/jcmm.12725","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T09:28:19Z","timestamp":1448616499000},"page":"323-332","source":"Crossref","is-referenced-by-count":30,"title":["iPSC\u2010derived human cardiac progenitor cells improve ventricular remodelling <i>via<\/i> angiogenesis and interstitial networking of infarcted myocardium"],"prefix":"10.1111","volume":"20","author":[{"given":"KP Myu Mia","family":"Ja","sequence":"first","affiliation":[{"name":"National Heart Research Institute Singapore National Heart Centre Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"Miao","sequence":"additional","affiliation":[{"name":"National Heart Research Institute Singapore National Heart Centre Singapore Singapore"},{"name":"Department of Pharmacology Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole Gui Zhen","family":"Tee","sequence":"additional","affiliation":[{"name":"National Heart Research Institute Singapore National Heart Centre Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sze Yun","family":"Lim","sequence":"additional","affiliation":[{"name":"National Heart Research Institute Singapore National Heart Centre Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manasi","family":"Nandihalli","sequence":"additional","affiliation":[{"name":"National Heart Research Institute Singapore National Heart Centre Singapore 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