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This study is aimed at evaluating the numbers of different subsets of circulating memory B cells, plasmablasts, and the levels of serum immunoglobulin in UC<\/jats:styled-content> patients. Total of 23 patients with active UC<\/jats:styled-content> and 14 healthy controls (HC<\/jats:styled-content>) were examined for the numbers of different subsets of circulating memory B cells and plasmablasts before and after treatment with mesalazine for 8\u201312\u00a0weeks by flow cytometry. Disease activity was evaluated by the Mayo clinic score. The levels of serum immunoglobulin, C\u2010reactive protein (CRP<\/jats:styled-content>) and erythrocyte sedimentation rate (ESR<\/jats:styled-content>) were measured in individual subjects. In comparison with that in HC<\/jats:styled-content>, significantly reduced numbers of IgG+<\/jats:sup>\u00a0IgD\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>27+<\/jats:sup>\u00a0CD<\/jats:styled-content>19+<\/jats:sup> memory B cells, increased numbers of CD<\/jats:styled-content>20\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>19+<\/jats:sup> plasmablast subsets, and higher serum IgG levels were detected in UC<\/jats:styled-content> patients. The concentrations of serum IgG, the numbers of CD<\/jats:styled-content>138+<\/jats:sup>\u00a0CD<\/jats:styled-content>38+<\/jats:sup>\u00a0CD<\/jats:styled-content>20\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>19+<\/jats:sup>, and IgG+<\/jats:sup>\u00a0CD<\/jats:styled-content>38+<\/jats:sup>\u00a0CD<\/jats:styled-content>20\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>19+<\/jats:sup> plasmablasts were negatively associated with the numbers of IgG+<\/jats:sup>\u00a0IgD\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>27+<\/jats:sup>\u00a0CD<\/jats:styled-content>19+<\/jats:sup> memory B cells. Furthermore, the values of Mayo clinic score, CRP<\/jats:styled-content>, or ESR<\/jats:styled-content> in UC<\/jats:styled-content> patients were negatively correlated with the numbers of IgG+<\/jats:sup>\u00a0IgD\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>27+<\/jats:sup>\u00a0CD<\/jats:styled-content>19+<\/jats:sup> memory B cells, while positively correlated with the serum IgG levels and the numbers of plasmablast subsets. Following treatment with mesalazine, the numbers of circulating IgG+<\/jats:sup>\u00a0IgD\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>27+<\/jats:sup>\u00a0CD<\/jats:styled-content>19+<\/jats:sup> memory B cells were significantly increased, while the numbers of CD<\/jats:styled-content>138+<\/jats:sup>\u00a0CD<\/jats:styled-content>38+<\/jats:sup>\u00a0CD<\/jats:styled-content>20\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>19+<\/jats:sup> and IgG+<\/jats:sup>\u00a0CD<\/jats:styled-content>38+<\/jats:sup>\u00a0CD<\/jats:styled-content>20\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>19+<\/jats:sup> plasmablasts were reduced in UC<\/jats:styled-content> patients. These decreased IgG+<\/jats:sup>\u00a0IgD\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>27+<\/jats:sup>\u00a0CD<\/jats:styled-content>19+<\/jats:sup> memory B cells and increased plasmablasts may be involved in the pathogenic process of UC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.12728","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T18:06:48Z","timestamp":1453486008000},"page":"804-814","source":"Crossref","is-referenced-by-count":23,"title":["Circulating memory B cells and plasmablasts are associated with the levels of serum immunoglobulin in patients with ulcerative colitis"],"prefix":"10.1111","volume":"20","author":[{"given":"Xinrui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Central Laboratory The First Hospital Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory The First Hospital Jilin University Changchun China"},{"name":"Key Laboratory of Zoonosis Research Ministry of Education The First Hospital Jilin University Changchun China"},{"name":"Jiangsu Co\u2010innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology China\u2010Japan Union Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory The First Hospital Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory The First Hospital Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory The First Hospital Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pujun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory The First Hospital Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,22]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"127","article-title":"Etiology and pathogenesis of inflammatory bowel disease","volume":"51","author":"Schmidt C","year":"2005","journal-title":"Minerva Gastroenterol 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