{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:33:45Z","timestamp":1759826025276},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Department of Wenzhou","award":["Y20140693"],"award-info":[{"award-number":["Y20140693"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Xeroderma pigmentosum group G (<jats:italic><jats:styled-content style=\"fixed-case\">XPG<\/jats:styled-content><\/jats:italic>) protein plays an important role in the <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair process by cutting the damaged <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> at the 3\u2032 terminus. Previous studies have indicated some polymorphisms in the <jats:italic><jats:styled-content style=\"fixed-case\">XPG<\/jats:styled-content><\/jats:italic> gene are associated with stomach cancer susceptibility. We performed this hospital\u2010based case\u2013control study to evaluate the association of four potentially functional <jats:italic><jats:styled-content style=\"fixed-case\">XPG<\/jats:styled-content><\/jats:italic> polymorphisms (rs2094258 C&gt;T, rs751402 C&gt;T, rs2296147 T&gt;C and rs873601G&gt;A) with stomach cancer susceptibility. The four single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) were genotyped in 692 stomach cancer cases and 771 healthy controls. Logistic regression analysis was conducted, and odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were used to assess the association of interest. Of the studied <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s, <jats:italic><jats:styled-content style=\"fixed-case\">XPG<\/jats:styled-content><\/jats:italic> rs873601G&gt;A polymorphism was found to significantly associate with stomach cancer susceptibility (<jats:styled-content style=\"fixed-case\">AA <\/jats:styled-content><jats:italic>versus <\/jats:italic><jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content> = 1.31, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.03\u20131.66, <jats:italic>P<\/jats:italic> = 0.027). Combined analysis of all <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s revealed that the individuals with two of risk genotypes had a significantly increased stomach cancer risk (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.52, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.13\u20132.06). In the stratification analysis, the association between the rs873601<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotype and stomach cancer risk was observed in older group (&gt;59 year), as well as patients with non\u2010cardia stomach cancer. Further combined analysis indicated men, smokers, or non\u2010drinkers more than one risk genotypes had a significantly increased stomach cancer risk. Our results indicate that <jats:italic><jats:styled-content style=\"fixed-case\">XPG<\/jats:styled-content><\/jats:italic> rs873601G&gt;A polymorphism may be associated with the risk of stomach cancer. Further prospective studies with different ethnicities and large sample sizes are needed to validate our findings.<\/jats:p>","DOI":"10.1111\/jcmm.12773","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T17:22:54Z","timestamp":1454001774000},"page":"903-908","source":"Crossref","is-referenced-by-count":17,"title":["Association between <i><scp>XPG<\/scp><\/i> polymorphisms and stomach cancer susceptibility in a Chinese population"],"prefix":"10.1111","volume":"20","author":[{"given":"Yun\u2010Zhi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of General Surgery First Affiliated Hospital Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics People's Hospital Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of General Surgery First Affiliated Hospital Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Ru","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of General Surgery First Affiliated Hospital Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Jie","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of General Surgery First Affiliated Hospital Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi\u2010Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery First Affiliated Hospital Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Huashan Hospital Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery First Affiliated Hospital Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng\u2010Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of General Surgery First Affiliated Hospital Wenzhou Medical University Wenzhou Zhejiang 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