{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T17:38:18Z","timestamp":1778434698343,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200836"],"award-info":[{"award-number":["81200836"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370411"],"award-info":[{"award-number":["81370411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470591"],"award-info":[{"award-number":["81470591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570723"],"award-info":[{"award-number":["81570723"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["121100910400"],"award-info":[{"award-number":["121100910400"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["132102310247"],"award-info":[{"award-number":["132102310247"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["20112011A330002"],"award-info":[{"award-number":["20112011A330002"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","award":["NCET\u201013\u20100351"],"award-info":[{"award-number":["NCET\u201013\u20100351"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vascular dementia, being the most severe form of vascular cognitive impairment (<jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content>), is caused by cerebrovascular disease. Whether organophosphorus causes <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> remains unknown. Isocarbophos (0.5 mg\/kg per 2 days) was intragastrically administrated to rats for 16 weeks. The structure and function of cerebral arteries were assayed. The learning and memory were evaluated by serial tests of step\u2010down, step\u2010through and morris water maze. Long\u2010term administration of isocarbophos reduced the hippocampal acetylcholinesterase (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hE) activity and acetylcholine (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>h) content but did not alter the plasma <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hE activity, and significantly damaged the functions of learning and memory. Moreover, isocarbophos remarkably induced endothelial dysfunction in the middle cerebral artery and the expressions of <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">VCAM<\/jats:styled-content>\u20101 in the posterior cerebral artery. Morphological analysis by light microscopy and electron microscopy indicated disruptions of the hippocampus and vascular wall in the cerebral arteries from isocarbophos\u2010treated rats. Treatment of isocarbophos injured primary neuronal and astroglial cells isolated from rats. Correlation analysis demonstrated that there was a high correlation between vascular function of cerebral artery and hippocampal <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hE activity or <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>h content in rats. In conclusion, chronic administration of isocarbophos induces impairments of memory and learning, which is possibly related to cerebral vascular dysfunction.<\/jats:p>","DOI":"10.1111\/jcmm.12775","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T08:46:39Z","timestamp":1453970799000},"page":"731-739","source":"Crossref","is-referenced-by-count":16,"title":["Chronic administration of isocarbophos induces vascular cognitive impairment in rats"],"prefix":"10.1111","volume":"20","author":[{"given":"Peng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacology Pharmaceutical College Central South University Changsha China"},{"name":"College of Pharmacy Xinxiang Medical University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Ling","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences Tongji Medical School Huazhong University of Science and Technology Wuhan China"},{"name":"School of Basic Medical Sciences Xinxiang Medical University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo\u2010Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Sanqun Medical College Xinxiang Medical University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010Pin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Pharmaceutical College Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan\u2010Rong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Sanqun Medical College Xinxiang Medical University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Xiu","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Xinxiang Medical University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition The Affiliated Hospital Hunan Normal University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang\u2010Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Xinxiang Medical University Xinxiang China"},{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research Qilu Hospital Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Ping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Pharmaceutical College Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00302-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.01.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(01)00266-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.84.5.731"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90356-T"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1988.9934372"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2014.04.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2015.02.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03178266"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.06.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.11.026"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90976-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5576fje"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1179\/oeh.2002.8.1.27"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2012.07.007"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8182"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2014.01.003"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.09.021"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht239"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.2013.17.3.114"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.01.073"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.09.050"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00190-4"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.274"},{"key":"e_1_2_8_27_1","first-page":"172","article-title":"Effects of trichlorfon on atherosclerosis and PON1 activity in rabbits","volume":"3","author":"Hu M","year":"2009","journal-title":"Journal of Chinese Atherosclerosis"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01990952"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1997.2302"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12061"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.07.034"},{"key":"e_1_2_8_32_1","first-page":"CD008900","article-title":"Cerebrolysin for vascular dementia","volume":"1","author":"Chen N","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100037252"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2000.22.2.796070"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00017"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12775","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.12775","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T19:33:47Z","timestamp":1695756827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,28]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/jcmm.12775"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12775","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,28]]}}}